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Assay Detail

CHEMBL2340872

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Displacement of [3H](+)-pentazocine from sigma-1 receptor in guinea pig brain
ChEMBL ↗
50
Total Activities
25
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Cavia porcellus
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

Sigma non-opioid intracellular receptor 1 (CHEMBL4153) ↗
Type SINGLE PROTEIN
Organism Cavia porcellus

Publication

3D-QSAR and docking studies of pentacycloundecylamines at the sigma-1 (σ1) receptor.
Geldenhuys WJ, Novotny N, Malan SF, Van der Schyf CJ.
Bioorg Med Chem Lett (2013) 23 : 1707 -1711
PubMed 23414839 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 50 6.28 8.05

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL2205821 — — 2 8.05
CHEMBL602850 — — 2 8.00
CHEMBL2332492 — — 2 8.00
CHEMBL2332494 — — 2 8.00
CHEMBL1190672 — — 2 7.77
CHEMBL2205835 — — 2 7.70
CHEMBL2205819 — — 2 7.68
CHEMBL2332493 — — 2 7.68
CHEMBL1189111 — — 2 7.17
CHEMBL1194508 — — 2 7.14
CHEMBL2332502 — — 2 7.09
CHEMBL2332504 — — 2 7.07
CHEMBL2332496 — — 2 7.01
CHEMBL2205825 — — 2 6.99
CHEMBL1189234 — — 2 6.99
CHEMBL2332501 — — 2 6.97
CHEMBL1189714 — — 2 6.91
CHEMBL608560 — — 2 6.82
CHEMBL2332503 — — 2 6.77
CHEMBL2332499 — — 2 6.74
CHEMBL2332495 — — 2 6.73
CHEMBL2332500 — — 2 6.70
CHEMBL348313 — — 2 6.68
CHEMBL2332497 — — 2 6.57
CHEMBL2332498 — — 2 5.96

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL2205821 — Ki = 8.913 nM 8.05
CHEMBL602850 — Ki = 10.0 nM 8.00
CHEMBL2332494 — Ki = 10.0 nM 8.00
CHEMBL2332492 — Ki = 10.0 nM 8.00
CHEMBL1190672 — Ki = 16.98 nM 7.77
CHEMBL2205835 — Ki = 19.95 nM 7.70
CHEMBL2205819 — Ki = 20.89 nM 7.68
CHEMBL2332493 — Ki = 20.89 nM 7.68
CHEMBL1189111 — Ki = 67.61 nM 7.17
CHEMBL1194508 — Ki = 72.44 nM 7.14
CHEMBL2332502 — Ki = 81.28 nM 7.09
CHEMBL2332504 — Ki = 85.11 nM 7.07
CHEMBL2332496 — Ki = 97.72 nM 7.01
CHEMBL1189234 — Ki = 102.33 nM 6.99
CHEMBL2205825 — Ki = 102.33 nM 6.99
CHEMBL2332501 — Ki = 107.15 nM 6.97
CHEMBL1189714 — Ki = 123.03 nM 6.91
CHEMBL608560 — Ki = 151.36 nM 6.82
CHEMBL2332503 — Ki = 169.82 nM 6.77
CHEMBL2332499 — Ki = 181.97 nM 6.74
CHEMBL2332495 — Ki = 186.21 nM 6.73
CHEMBL2332500 — Ki = 199.53 nM 6.70
CHEMBL348313 — Ki = 208.93 nM 6.68
CHEMBL2332497 — Ki = 269.15 nM 6.57
CHEMBL2332498 — Ki = 1096.48 nM 5.96
CHEMBL2205821 — Ki = 9000.0 nM 5.05
CHEMBL2332492 — Ki = 10000.0 nM 5.00
CHEMBL2332494 — Ki = 10000.0 nM 5.00
CHEMBL602850 — Ki = 10000.0 nM 5.00
CHEMBL1190672 — Ki = 17000.0 nM 4.77
CHEMBL2205835 — Ki = 20000.0 nM 4.70
CHEMBL2332493 — Ki = 21000.0 nM 4.68
CHEMBL2205819 — Ki = 21000.0 nM 4.68
CHEMBL1189111 — Ki = 67000.0 nM 4.17
CHEMBL1194508 — Ki = 72000.0 nM 4.14
CHEMBL2332502 — Ki = 81000.0 nM 4.09
CHEMBL2332504 — Ki = 86000.0 nM 4.07
CHEMBL2332496 — Ki = 97000.0 nM 4.01
CHEMBL2332495 — Ki = 186000.0 nM -
CHEMBL1189714 — Ki = 124000.0 nM -
CHEMBL1189234 — Ki = 103000.0 nM -
CHEMBL348313 — Ki = 208000.0 nM -
CHEMBL2332503 — Ki = 169000.0 nM -
CHEMBL2332501 — Ki = 107000.0 nM -
CHEMBL608560 — Ki = 152000.0 nM -
CHEMBL2332499 — Ki = 182000.0 nM -
CHEMBL2332500 — Ki = 198000.0 nM -
CHEMBL2205825 — Ki = 103000.0 nM -
CHEMBL2332497 — Ki = 270000.0 nM -
CHEMBL2332498 — Ki = 1100000.0 nM -