Assay Detail
Binding
CHEMBL2340914
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Agonist activity at 5-HT2B receptor (unknown origin)
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Synthesis and SAR of 2,3,3a,4-tetrahydro-1H-pyrrolo[3,4-c]isoquinolin-5(9bH)-ones as 5-HT2C receptor agonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 3 | 8.19 | 8.89 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL360328 | LORCASERIN | 4.0 | 1 | 8.89 |
| CHEMBL2337102 | — | — | 1 | 7.85 |
| CHEMBL2337103 | — | — | 1 | 7.82 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL360328 | LORCASERIN | Ki | = | 1.3 | nM | 8.89 |
| CHEMBL2337102 | — | Ki | = | 14.0 | nM | 7.85 |
| CHEMBL2337103 | — | Ki | = | 15.0 | nM | 7.82 |