Assay Detail
Binding
CHEMBL2340951
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Inhibition of human CYP17 expressed in Escherichia coli co-expressing rat NADPH-P450-reductase using progesterone as substrate
17
Total Activities
17
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Steroid 17-alpha-hydroxylase/17,20 lyase (CHEMBL3522) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Modulation of cytochromes P450 with xanthone-based molecules: from aromatase to aldosterone synthase and steroid 11β-hydroxylase inhibition.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 17 | 6.40 | 7.38 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL78322 | — | — | 1 | 7.38 |
| CHEMBL254328 | ABIRATERONE | 3.0 | 1 | 7.14 |
| CHEMBL307160 | — | — | 1 | 6.89 |
| CHEMBL442373 | — | — | 1 | 6.66 |
| CHEMBL2333326 | — | — | 1 | 6.58 |
| CHEMBL2333336 | — | — | 1 | 6.31 |
| CHEMBL2333329 | — | — | 1 | 6.21 |
| CHEMBL2333331 | — | — | 1 | 5.90 |
| CHEMBL2333327 | — | — | 1 | 5.87 |
| CHEMBL2333337 | — | — | 1 | 5.76 |
| CHEMBL2333328 | — | — | 1 | 5.72 |
| CHEMBL2333332 | — | — | 1 | - |
| CHEMBL2333330 | — | — | 1 | - |
| CHEMBL2333333 | — | — | 1 | - |
| CHEMBL2333334 | — | — | 1 | - |
| CHEMBL2333335 | — | — | 1 | - |
| CHEMBL9298 | FADROZOLE | 2.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL78322 | — | IC50 | = | 42.0 | nM | 7.38 |
| CHEMBL254328 | ABIRATERONE | IC50 | = | 72.0 | nM | 7.14 |
| CHEMBL307160 | — | IC50 | = | 130.0 | nM | 6.89 |
| CHEMBL442373 | — | IC50 | = | 220.0 | nM | 6.66 |
| CHEMBL2333326 | — | IC50 | = | 260.0 | nM | 6.58 |
| CHEMBL2333336 | — | IC50 | = | 493.0 | nM | 6.31 |
| CHEMBL2333329 | — | IC50 | = | 610.0 | nM | 6.21 |
| CHEMBL2333331 | — | IC50 | = | 1250.0 | nM | 5.90 |
| CHEMBL2333327 | — | IC50 | = | 1346.0 | nM | 5.87 |
| CHEMBL2333337 | — | IC50 | = | 1737.0 | nM | 5.76 |
| CHEMBL2333328 | — | IC50 | = | 1886.0 | nM | 5.72 |
| CHEMBL2333332 | — | IC50 | > | 5000.0 | nM | - |
| CHEMBL2333330 | — | IC50 | > | 5000.0 | nM | - |
| CHEMBL2333333 | — | IC50 | > | 5000.0 | nM | - |
| CHEMBL2333334 | — | IC50 | > | 5000.0 | nM | - |
| CHEMBL2333335 | — | IC50 | > | 5000.0 | nM | - |
| CHEMBL9298 | FADROZOLE | IC50 | > | 5000.0 | nM | - |