Assay Detail
Binding
CHEMBL2340965
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Inhibition of HDAC8 (unknown origin) assessed as fluorescence intensity measured after 60 mins incubation at room temperature by trypsin-free microfluidic lab-on-a-chip assay
15
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Potent and selective inhibition of histone deacetylase 6 (HDAC6) does not require a surface-binding motif.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 15 | 5.78 | 6.37 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2333344 | — | — | 1 | 6.37 |
| CHEMBL2018302 | TUBASTATIN A | — | 1 | 6.17 |
| CHEMBL2333342 | — | — | 1 | 6.16 |
| CHEMBL154574 | — | — | 1 | 6.12 |
| CHEMBL98 | VORINOSTAT | 4.0 | 1 | 5.99 |
| CHEMBL2333341 | — | — | 1 | 5.99 |
| CHEMBL2333346 | — | — | 1 | 5.96 |
| CHEMBL2333340 | — | — | 1 | 5.94 |
| CHEMBL2333339 | — | — | 1 | 5.88 |
| CHEMBL16300 | BENZOHYDROXAMATE | — | 1 | 5.72 |
| CHEMBL2333343 | — | — | 1 | 5.71 |
| CHEMBL152162 | — | — | 1 | 5.63 |
| CHEMBL2333345 | — | — | 1 | 5.43 |
| CHEMBL152665 | PHENYLACETOHYDROXAMIC ACID | — | 1 | 4.93 |
| CHEMBL2333338 | — | — | 1 | 4.68 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2333344 | — | IC50 | = | 431.0 | nM | 6.37 |
| CHEMBL2018302 | TUBASTATIN A | IC50 | = | 681.0 | nM | 6.17 |
| CHEMBL2333342 | — | IC50 | = | 689.0 | nM | 6.16 |
| CHEMBL154574 | — | IC50 | = | 759.0 | nM | 6.12 |
| CHEMBL98 | VORINOSTAT | IC50 | = | 1020.0 | nM | 5.99 |
| CHEMBL2333341 | — | IC50 | = | 1030.0 | nM | 5.99 |
| CHEMBL2333346 | — | IC50 | = | 1090.0 | nM | 5.96 |
| CHEMBL2333340 | — | IC50 | = | 1150.0 | nM | 5.94 |
| CHEMBL2333339 | — | IC50 | = | 1330.0 | nM | 5.88 |
| CHEMBL16300 | BENZOHYDROXAMATE | IC50 | = | 1920.0 | nM | 5.72 |
| CHEMBL2333343 | — | IC50 | = | 1950.0 | nM | 5.71 |
| CHEMBL152162 | — | IC50 | = | 2350.0 | nM | 5.63 |
| CHEMBL2333345 | — | IC50 | = | 3720.0 | nM | 5.43 |
| CHEMBL152665 | PHENYLACETOHYDROXAMIC ACID | IC50 | = | 11620.0 | nM | 4.93 |
| CHEMBL2333338 | — | IC50 | = | 20910.0 | nM | 4.68 |