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Compound Detail

CHEMBL2333343

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CNC(=O)c1ccc(C(=O)NO)cc1

Basic Information

ChEMBL ID CHEMBL2333343
Phase Preclinical
Structure Type MOL
InChI Key PVWFSNDIULQQLV-UHFFFAOYSA-N
3
Targets
3
Activities
1
Assay Types
0
PK Parameters
6
Publications
0
Known Names

Molecular Properties

194.2
MW (Da)
0.17
ALogP
3
HBA
3
HBD
78.4
PSA (Ų)
0.46
QED
0
Ro5 Violations
2
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C9H10N2O3
MW 194.19
Aromatic Rings 1
Heavy Atoms 14
NP-Likeness -0.65

Activity Summary

IC50 3 meas. best 7.55

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Histone deacetylase 6
CHEMBL1865
IC50 7.55 7.55 28.0 1
Histone deacetylase 2
CHEMBL1937
IC50 5.79 5.79 1610.0 1
Histone deacetylase 8
CHEMBL3192
IC50 5.71 5.71 1950.0 1

Activity Data Samples

Top measurements by pChEMBL value

Literature References

PubMed DOI Target Context # Activities
23368884 10.1021/jm301355j Histone deacetylase 2 2
23368884 10.1021/jm301355j Histone deacetylase 6 2
23368884 10.1021/jm301355j Histone deacetylase 3 1
23368884 10.1021/jm301355j Histone deacetylase 1 1
23368884 10.1021/jm301355j Histone deacetylase 8 1
23368884 10.1021/jm301355j Histone deacetylase 4 1

Data from ChEMBL 36 via Core Engine