Assay Detail

CHEMBL2341010

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Binding

Inhibition of COX1 in human whole blood assessed as reduction in TXB2 generation

ChEMBL ↗

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Target

Prostaglandin G/H synthase 1 (CHEMBL221) ↗

Open DB target context

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Prostaglandin G/H synthase 1 (CHEMBL221) is the working anchor for this assay review. Loading the live Open DB target snapshot…

Primary target Prostaglandin G/H synthase 1

CHEMBL221

Anchored from Assay target.

Protein identity Prostaglandin G/H synthase 1

Disease frame Disease evidence pending

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Review focus Open DB context pending

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Total Activities

Compounds Tested

Activity Types

Assay Parameters

Assay Information

Assay Type	Binding
Organism	Homo sapiens
Tissue	Blood
Confidence	9 — Direct single protein target
Curated By	Autocuration

Target

Prostaglandin G/H synthase 1 (CHEMBL221) ↗

Type	SINGLE PROTEIN
Organism	Homo sapiens

Publication

Novel analgesic/anti-inflammatory agents: 1,5-diarylpyrrole nitrooxyalkyl ethers and related compounds as cyclooxygenase-2 inhibiting nitric oxide donors.

Anzini M, Di Capua A, Valenti S, Brogi S, Rovini M, Giuliani G, Cappelli A, Vomero S, Chiasserini L, Sega A, Poce G, Giorgi G, Calderone V, Martelli A, Testai L, Sautebin L, Rossi A, Pace S, Ghelardini C, Di Cesare Mannelli L, Benetti V, Giordani A, Anzellotti P, Dovizio M, Patrignani P, Biava M.
J Med Chem (2013) 56 : 3191 -3206
PubMed 23534442 · DOI

Activity Statistics

Type	Count	Avg pChEMBL	Best pChEMBL
IC80	2	-	-
IC50	2	4.60	4.70
Inhibition	2	-	-

Compounds Tested

Compound	Name	Phase	Activities	Best pChEMBL
CHEMBL2337409	—	—	3	4.70
CHEMBL2337402	—	—	3	4.50

Activity Data

Compound	Name	Type	Rel.	Value	Units	pChEMBL
CHEMBL2337409	—	IC50	=	20000.0	nM	4.70
CHEMBL2337402	—	IC50	=	31240.0	nM	4.50
CHEMBL2337409	—	IC80	=	37.14	uM	-
CHEMBL2337402	—	IC80	=	63.3	uM	-
CHEMBL2337409	—	Inhibition		-	%	-
CHEMBL2337402	—	Inhibition		-	%	-