Assay Detail
Binding
CHEMBL2341306
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Inhibition of human carbonic anhydrase 1 preincubated for 15 mins by CO2 hydration stopped-flow assay
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Synthesis of C-cinnamoyl glycosides and their inhibitory activity against mammalian carbonic anhydrases.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 9 | 5.21 | 5.44 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2323139 | — | — | 1 | 5.44 |
| CHEMBL550572 | — | — | 1 | 5.43 |
| CHEMBL2323136 | — | — | 1 | 5.29 |
| CHEMBL2323140 | — | — | 1 | 5.26 |
| CHEMBL2323135 | — | — | 1 | 5.24 |
| CHEMBL2323138 | — | — | 1 | 5.17 |
| CHEMBL2323134 | — | — | 1 | 5.07 |
| CHEMBL2323137 | — | — | 1 | 5.03 |
| CHEMBL14060 | PHENOL | 4.0 | 1 | 4.99 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2323139 | — | Ki | = | 3600.0 | nM | 5.44 |
| CHEMBL550572 | — | Ki | = | 3700.0 | nM | 5.43 |
| CHEMBL2323136 | — | Ki | = | 5100.0 | nM | 5.29 |
| CHEMBL2323140 | — | Ki | = | 5500.0 | nM | 5.26 |
| CHEMBL2323135 | — | Ki | = | 5700.0 | nM | 5.24 |
| CHEMBL2323138 | — | Ki | = | 6800.0 | nM | 5.17 |
| CHEMBL2323134 | — | Ki | = | 8500.0 | nM | 5.07 |
| CHEMBL2323137 | — | Ki | = | 9300.0 | nM | 5.03 |
| CHEMBL14060 | PHENOL | Ki | = | 10200.0 | nM | 4.99 |