Assay Detail
Binding
CHEMBL2341787
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Inhibition of human recombinant carbonic anhydrase 1 preincubated for 15 mins by CO2 hydration stopped-flow assay
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Salicylaldoxime derivatives as new leads for the development of carbonic anhydrase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 9 | 5.07 | 5.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1782957 | — | — | 1 | 5.40 |
| CHEMBL479638 | — | — | 1 | 5.16 |
| CHEMBL449451 | — | — | 1 | 5.16 |
| CHEMBL1782958 | — | — | 1 | 5.14 |
| CHEMBL272457 | — | — | 1 | 5.12 |
| CHEMBL479836 | — | — | 1 | 5.12 |
| CHEMBL272458 | — | — | 1 | 5.10 |
| CHEMBL475278 | — | — | 1 | 5.04 |
| CHEMBL259068 | — | — | 1 | 4.41 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1782957 | — | Ki | = | 3980.0 | nM | 5.40 |
| CHEMBL479638 | — | Ki | = | 6900.0 | nM | 5.16 |
| CHEMBL449451 | — | Ki | = | 6930.0 | nM | 5.16 |
| CHEMBL1782958 | — | Ki | = | 7270.0 | nM | 5.14 |
| CHEMBL272457 | — | Ki | = | 7650.0 | nM | 5.12 |
| CHEMBL479836 | — | Ki | = | 7570.0 | nM | 5.12 |
| CHEMBL272458 | — | Ki | = | 7880.0 | nM | 5.10 |
| CHEMBL475278 | — | Ki | = | 9130.0 | nM | 5.04 |
| CHEMBL259068 | — | Ki | = | 38810.0 | nM | 4.41 |