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Assay Detail

CHEMBL2341925

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of MMP1 (unknown origin)
14
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

Interstitial collagenase (CHEMBL332)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Sulphonamides: Deserving class as MMP inhibitors?
Jain P, Saravanan C, Singh SK.
Eur J Med Chem (2013) 60 : 89 -100
PubMed 23287054 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 14 6.29 6.76

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL81113 1 6.76
CHEMBL78826 1 6.19
CHEMBL421699 1 5.91
CHEMBL2337131 1 -
CHEMBL147489 1 -
CHEMBL2337130 1 -
CHEMBL83209 1 -
CHEMBL310008 1 -
CHEMBL114815 1 -
CHEMBL421882 1 -
CHEMBL330028 1 -
CHEMBL311932 1 -
CHEMBL226439 1 -
CHEMBL181244 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL81113 IC50 = 174.0 nM 6.76
CHEMBL78826 IC50 = 639.0 nM 6.19
CHEMBL421699 IC50 = 1227.0 nM 5.91
CHEMBL2337131 IC50 - -
CHEMBL147489 IC50 = 0.041 nM -
CHEMBL2337130 IC50 - -
CHEMBL83209 IC50 - -
CHEMBL310008 IC50 - -
CHEMBL114815 IC50 - -
CHEMBL421882 IC50 - -
CHEMBL330028 IC50 - -
CHEMBL311932 IC50 - -
CHEMBL226439 IC50 - -
CHEMBL181244 IC50 - -