Assay Detail
Binding
CHEMBL2343015
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human ERG assessed as decrease in tail current amplitude measured after 5 mins by whole cell patch clamp technique
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Voltage-gated inwardly rectifying potassium channel KCNH2 (CHEMBL240) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Discovery of novel N-substituted oxindoles as selective m1 and m4 muscarinic acetylcholine receptors partial agonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 5.65 | 6.10 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2336055 | — | — | 1 | 6.10 |
| CHEMBL2336059 | — | — | 1 | 5.62 |
| CHEMBL2336056 | — | — | 1 | 5.46 |
| CHEMBL2336057 | — | — | 1 | 5.41 |
| CHEMBL2336058 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2336055 | — | IC50 | = | 800.0 | nM | 6.10 |
| CHEMBL2336059 | — | IC50 | = | 2400.0 | nM | 5.62 |
| CHEMBL2336056 | — | IC50 | = | 3500.0 | nM | 5.46 |
| CHEMBL2336057 | — | IC50 | = | 3900.0 | nM | 5.41 |
| CHEMBL2336058 | — | IC50 | - | — | - |