Compound Detail
CHEMBL2336055
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Basic Information
| ChEMBL ID | CHEMBL2336055 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | BPIMWCPHYBQONW-SFHVURJKSA-N |
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
6
Publications
0
Known Names
Molecular Properties
371.5
MW (Da)
2.52
ALogP
4
HBA
0
HBD
53.1
PSA (Ų)
0.82
QED
0
Ro5 Violations
4
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 1 meas. best 6.1
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Voltage-gated inwardly rectifying potassium channel KCNH2 CHEMBL240 | IC50 | 6.1 | 6.1 | 800.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Voltage-gated inwardly rectifying potassium channel KCNH2 | IC50 | = | 800.0 | nM | 6.1 | Inhibition of human ERG assessed as decrease in tail current amplitude measured ... | 24900656 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 24900656 | 10.1021/ml300372f | Muscarinic acetylcholine receptor M5 | 2 |
| 24900656 | 10.1021/ml300372f | Muscarinic acetylcholine receptor M3 | 2 |
| 24900656 | 10.1021/ml300372f | Muscarinic acetylcholine receptor M2 | 2 |
| 24900656 | 10.1021/ml300372f | Muscarinic acetylcholine receptor M1 | 2 |
| 24900656 | 10.1021/ml300372f | Muscarinic acetylcholine receptor M4 | 2 |
| 24900656 | 10.1021/ml300372f | Voltage-gated inwardly rectifying potassium channel KCNH2 | 1 |
Data from ChEMBL 36 via Core Engine