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Assay Detail

CHEMBL2343418

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of jack bean beta hexosaminidase
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Canavalia ensiformis
Confidence 0 — Uncurated / Unknown
Curated By Autocuration

Target

Unchecked (CHEMBL612545)
Type UNCHECKED

Publication

Pharmacological chaperones as therapeutics for lysosomal storage diseases.
Boyd RE, Lee G, Rybczynski P, Benjamin ER, Khanna R, Wustman BA, Valenzano KJ.
J Med Chem (2013) 56 : 2705 -2725
PubMed 23363020 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 3 6.92 8.30

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL2333322 ACETAMIDODEOXYNOJIRIMYCIN 1 8.30
CHEMBL1232979 1 6.30
CHEMBL382689 ACETAMIDODIDEOXYNOJIRIMYCIN 1 6.16

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL2333322 ACETAMIDODEOXYNOJIRIMYCIN Ki = 5.0 nM 8.30
CHEMBL1232979 Ki = 500.0 nM 6.30
CHEMBL382689 ACETAMIDODIDEOXYNOJIRIMYCIN Ki = 700.0 nM 6.16