Assay Detail
Binding
CHEMBL2343535
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human PDE4B2
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
3',5'-cyclic-AMP phosphodiesterase 4B (CHEMBL275) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Benzoquinones and terphenyl compounds as phosphodiesterase-4B inhibitors from a fungus of the order Chaetothyriales (MSX 47445).
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 4.76 | 5.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL63 | ROLIPRAM | 2.0 | 1 | 5.40 |
| CHEMBL2331809 | BETULINAN C | — | 1 | 4.77 |
| CHEMBL2331810 | — | — | 1 | 4.51 |
| CHEMBL467203 | BETULINAN A | — | 1 | 4.36 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL63 | ROLIPRAM | IC50 | = | 4000.0 | nM | 5.40 |
| CHEMBL2331809 | BETULINAN C | IC50 | = | 17000.0 | nM | 4.77 |
| CHEMBL2331810 | — | IC50 | = | 31000.0 | nM | 4.51 |
| CHEMBL467203 | BETULINAN A | IC50 | = | 44000.0 | nM | 4.36 |