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Assay Detail

CHEMBL2344102

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of recombinant human carbonic anhydrase 1 after 15 mins by stopped flow CO2 hydration assay
16
Total Activities
16
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

Carbonic anhydrase 1 (CHEMBL261)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Optimization of heterocyclic substituted benzenesulfonamides as novel carbonic anhydrase IX inhibitors and their structure activity relationship.
Gao R, Liao S, Zhang C, Zhu W, Wang L, Huang J, Zhao Z, Li H, Qian X, Xu Y.
Eur J Med Chem (2013) 62 : 597 -604
PubMed 23429054 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 16 6.80 7.17

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL19 METHAZOLAMIDE 4.0 1 7.17
CHEMBL2336906 1 7.07
CHEMBL2336901 1 6.66
CHEMBL20 ACETAZOLAMIDE 4.0 1 6.29
CHEMBL2336905 1 -
CHEMBL2336904 1 -
CHEMBL2336903 1 -
CHEMBL2336902 1 -
CHEMBL2336900 1 -
CHEMBL2336899 1 -
CHEMBL2336898 1 -
CHEMBL2336897 1 -
CHEMBL2336896 1 -
CHEMBL2336895 1 -
CHEMBL2336894 1 -
CHEMBL2313213 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL19 METHAZOLAMIDE IC50 = 67.6 nM 7.17
CHEMBL2336906 IC50 = 85.7 nM 7.07
CHEMBL2336901 IC50 = 220.2 nM 6.66
CHEMBL20 ACETAZOLAMIDE IC50 = 509.6 nM 6.29
CHEMBL2336905 IC50 > 10000.0 nM -
CHEMBL2336904 IC50 > 10000.0 nM -
CHEMBL2336903 IC50 > 10000.0 nM -
CHEMBL2336902 IC50 > 10000.0 nM -
CHEMBL2336900 IC50 > 10000.0 nM -
CHEMBL2336899 IC50 > 10000.0 nM -
CHEMBL2336898 IC50 > 10000.0 nM -
CHEMBL2336897 IC50 > 10000.0 nM -
CHEMBL2336896 IC50 > 10000.0 nM -
CHEMBL2336895 IC50 > 10000.0 nM -
CHEMBL2336894 IC50 > 10000.0 nM -
CHEMBL2313213 IC50 > 10000.0 nM -