Assay Detail
Binding
CHEMBL2344116
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of recombinant MEK1 (unknown origin) by cascade reaction assay
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Dual specificity mitogen-activated protein kinase kinase 1 (CHEMBL3587) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Monocarbonyl curcumin analogues: heterocyclic pleiotropic kinase inhibitors that mediate anticancer properties.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 5.11 | 5.96 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL574646 | — | — | 1 | 5.96 |
| CHEMBL2338333 | — | — | 1 | 5.05 |
| CHEMBL379849 | — | — | 1 | 4.89 |
| CHEMBL2036343 | — | — | 1 | 4.52 |
| CHEMBL2338335 | — | — | 1 | - |
| CHEMBL2338334 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL574646 | — | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL2338333 | — | IC50 | = | 9000.0 | nM | 5.05 |
| CHEMBL379849 | — | IC50 | = | 12800.0 | nM | 4.89 |
| CHEMBL2036343 | — | IC50 | = | 30000.0 | nM | 4.52 |
| CHEMBL2338335 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL2338334 | — | IC50 | > | 100000.0 | nM | - |