Assay Detail
Functional
CHEMBL2344178
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Cytotoxicity against human MDA1986 cells after 72 hrs by MTS assay
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Antiproliferative withanolides from Datura wrightii.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 5.69 | 6.10 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL517080 | WITHAFERIN A | 1.0 | 1 | 6.10 |
| CHEMBL2333592 | WITHAMETELIN F | — | 1 | 5.82 |
| CHEMBL2333166 | WITHAMETELIN L | — | 1 | 5.64 |
| CHEMBL2333167 | WITHAMETELIN | — | 1 | 5.57 |
| CHEMBL2333591 | WITHAMETELIN O | — | 1 | 5.52 |
| CHEMBL2333165 | WITHAWRIGHTOLIDE | — | 1 | 5.51 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL517080 | WITHAFERIN A | IC50 | = | 800.0 | nM | 6.10 |
| CHEMBL2333592 | WITHAMETELIN F | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL2333166 | WITHAMETELIN L | IC50 | = | 2300.0 | nM | 5.64 |
| CHEMBL2333167 | WITHAMETELIN | IC50 | = | 2700.0 | nM | 5.57 |
| CHEMBL2333591 | WITHAMETELIN O | IC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL2333165 | WITHAWRIGHTOLIDE | IC50 | = | 3100.0 | nM | 5.51 |