Assay Detail
Functional
CHEMBL2344185
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Cytotoxicity against human RXF 393NL cells after 4 days by propidium iodide staining
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | RXF 393NL |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Optimization of inhibitors of the tyrosine kinase EphB4. 2. Cellular potency improvement and binding mode validation by X-ray crystallography.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 5.71 | 7.66 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5416410 | DASATINIB | 4.0 | 1 | 7.66 |
| CHEMBL566515 | — | — | 1 | 5.75 |
| CHEMBL2333602 | — | — | 1 | 5.58 |
| CHEMBL2333597 | — | — | 1 | 5.53 |
| CHEMBL2333593 | — | — | 1 | 5.25 |
| CHEMBL2333603 | — | — | 1 | 5.12 |
| CHEMBL2333595 | — | — | 1 | 5.06 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5416410 | DASATINIB | IC50 | = | 21.7 | nM | 7.66 |
| CHEMBL566515 | — | IC50 | = | 1760.0 | nM | 5.75 |
| CHEMBL2333602 | — | IC50 | = | 2630.0 | nM | 5.58 |
| CHEMBL2333597 | — | IC50 | = | 2930.0 | nM | 5.53 |
| CHEMBL2333593 | — | IC50 | = | 5580.0 | nM | 5.25 |
| CHEMBL2333603 | — | IC50 | = | 7600.0 | nM | 5.12 |
| CHEMBL2333595 | — | IC50 | = | 8690.0 | nM | 5.06 |