Assay Detail
Functional
CHEMBL2344189
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Cytotoxicity against human GXF251L cells after 4 days by propidium iodide staining
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Optimization of inhibitors of the tyrosine kinase EphB4. 2. Cellular potency improvement and binding mode validation by X-ray crystallography.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 4.99 | 5.65 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5416410 | DASATINIB | 4.0 | 1 | 5.65 |
| CHEMBL2333593 | — | — | 1 | 5.30 |
| CHEMBL2333602 | — | — | 1 | 4.90 |
| CHEMBL2333603 | — | — | 1 | 4.84 |
| CHEMBL2333595 | — | — | 1 | 4.83 |
| CHEMBL2333597 | — | — | 1 | 4.74 |
| CHEMBL566515 | — | — | 1 | 4.70 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5416410 | DASATINIB | IC50 | = | 2250.0 | nM | 5.65 |
| CHEMBL2333593 | — | IC50 | = | 4980.0 | nM | 5.30 |
| CHEMBL2333602 | — | IC50 | = | 12500.0 | nM | 4.90 |
| CHEMBL2333603 | — | IC50 | = | 14600.0 | nM | 4.84 |
| CHEMBL2333595 | — | IC50 | = | 14900.0 | nM | 4.83 |
| CHEMBL2333597 | — | IC50 | = | 18200.0 | nM | 4.74 |
| CHEMBL566515 | — | IC50 | = | 20200.0 | nM | 4.70 |