Assay Detail
Binding
CHEMBL2344634
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Inhibition of Yes1 (unknown origin) using [gamma-33P]ATP after 30 mins by radiometric assay
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Optimization of inhibitors of the tyrosine kinase EphB4. 2. Cellular potency improvement and binding mode validation by X-ray crystallography.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 6.55 | 6.79 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2333602 | — | — | 1 | 6.79 |
| CHEMBL2333603 | — | — | 1 | 6.55 |
| CHEMBL2333595 | — | — | 1 | 6.30 |
| CHEMBL566515 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2333602 | — | IC50 | = | 160.4 | nM | 6.79 |
| CHEMBL2333603 | — | IC50 | = | 284.0 | nM | 6.55 |
| CHEMBL2333595 | — | IC50 | = | 496.0 | nM | 6.30 |
| CHEMBL566515 | — | IC50 | - | — | - |