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Assay Detail

CHEMBL2344762

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of PTP1B (unknown origin) assessed as decrease in p-nitrophenol production from pNPP substrate after 30 mins by HTS7000 bioassay reader analysis
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

Tyrosine-protein phosphatase non-receptor type 1 (CHEMBL335)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Sesquiterpenes from the rhizomes of Curcuma heyneana.
Saifudin A, Tanaka K, Kadota S, Tezuka Y.
J Nat Prod (2013) 76 : 223 -229
PubMed 23387824 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 9 4.74 5.56

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL169 URSOLIC ACID 2.0 1 5.56
CHEMBL426373 1 5.25
CHEMBL2332435 ZERUMIN A 1 4.98
CHEMBL2332436 1 4.83
CHEMBL2332880 1 4.46
CHEMBL2332431 AERUGIDIOL 1 4.45
CHEMBL2332439 HEYNEANONES C 1 4.45
CHEMBL2332437 HEYNEANONE A 1 4.37
CHEMBL2332430 PROCURCUMENOL 1 4.34

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL169 URSOLIC ACID IC50 = 2750.0 nM 5.56
CHEMBL426373 IC50 = 5620.0 nM 5.25
CHEMBL2332435 ZERUMIN A IC50 = 10400.0 nM 4.98
CHEMBL2332436 IC50 = 14700.0 nM 4.83
CHEMBL2332880 IC50 = 35100.0 nM 4.46
CHEMBL2332431 AERUGIDIOL IC50 = 35700.0 nM 4.45
CHEMBL2332439 HEYNEANONES C IC50 = 35200.0 nM 4.45
CHEMBL2332437 HEYNEANONE A IC50 = 42500.0 nM 4.37
CHEMBL2332430 PROCURCUMENOL IC50 = 45600.0 nM 4.34