Assay Detail
Functional
CHEMBL2345236
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiinflammatory activity in human PBMCs assessed as inhibition of LPS-induced TNFalpha release incubated for 15 mins prior to LPS challenge measured after 24 hrs by HTRF assay
28
Total Activities
28
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | PBMC |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Structure-activity relationships of 6-(aminomethylphenoxy)-benzoxaborole derivatives as anti-inflammatory agent.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 28 | 6.28 | 8.15 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1201362 | CLOBETASOL | 3.0 | 1 | 8.15 |
| CHEMBL384467 | DEXAMETHASONE | 4.0 | 1 | 7.77 |
| CHEMBL2337318 | — | — | 1 | 7.39 |
| CHEMBL2337319 | — | — | 1 | 7.08 |
| CHEMBL2337323 | — | — | 1 | 6.38 |
| CHEMBL1761268 | — | — | 1 | 6.12 |
| CHEMBL10 | SB-203580 | — | 1 | 6.00 |
| CHEMBL2337324 | — | — | 1 | 5.80 |
| CHEMBL1761274 | — | — | 1 | 5.36 |
| CHEMBL2337333 | — | — | 1 | 5.23 |
| CHEMBL1761270 | — | — | 1 | 5.04 |
| CHEMBL2337322 | — | — | 1 | 5.00 |
| CHEMBL2337320 | — | — | 1 | - |
| CHEMBL2331615 | — | — | 1 | - |
| CHEMBL2337317 | — | — | 1 | - |
| CHEMBL2337316 | — | — | 1 | - |
| CHEMBL2337315 | — | — | 1 | - |
| CHEMBL3217028 | — | — | 1 | - |
| CHEMBL2337332 | — | — | 1 | - |
| CHEMBL2337331 | — | — | 1 | - |
| CHEMBL2337321 | — | — | 1 | - |
| CHEMBL2337329 | — | — | 1 | - |
| CHEMBL2337328 | — | — | 1 | - |
| CHEMBL2337327 | — | — | 1 | - |
| CHEMBL1761263 | — | — | 1 | - |
| CHEMBL2337326 | — | — | 1 | - |
| CHEMBL2337325 | — | — | 1 | - |
| CHEMBL2337330 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1201362 | CLOBETASOL | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL384467 | DEXAMETHASONE | IC50 | = | 17.0 | nM | 7.77 |
| CHEMBL2337318 | — | IC50 | = | 41.0 | nM | 7.39 |
| CHEMBL2337319 | — | IC50 | = | 83.0 | nM | 7.08 |
| CHEMBL2337323 | — | IC50 | = | 420.0 | nM | 6.38 |
| CHEMBL1761268 | — | IC50 | = | 750.0 | nM | 6.12 |
| CHEMBL10 | SB-203580 | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL2337324 | — | IC50 | = | 1600.0 | nM | 5.80 |
| CHEMBL1761274 | — | IC50 | = | 4400.0 | nM | 5.36 |
| CHEMBL2337333 | — | IC50 | = | 5900.0 | nM | 5.23 |
| CHEMBL1761270 | — | IC50 | = | 9100.0 | nM | 5.04 |
| CHEMBL2337322 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL2337320 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL2331615 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL2337317 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL2337316 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL2337315 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL3217028 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL2337332 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL2337331 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL2337321 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL2337329 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL2337328 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL2337327 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL1761263 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL2337326 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL2337325 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL2337330 | — | IC50 | > | 10000.0 | nM | - |