Compound Detail
CHEMBL2337318
Enter ChEMBL ID:
Free Research Context
This compound will appear in recent viewed items on the research home for this browser.
Research home
View demo workspace
Basic Information
| ChEMBL ID | CHEMBL2337318 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | FVJSMNWSMPYGML-UHFFFAOYSA-N |
| Parent Compound | CHEMBL3546188 |
| Active Moiety | CHEMBL3546188 |
1
Targets
3
Activities
1
Assay Types
8
PK Parameters
2
Publications
0
Known Names
Molecular Properties
273.1
MW (Da)
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 3 meas. best 7.48
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| PBMC CHEMBL613107 | IC50 | 7.48 | 7.4133 | 33.0 | 3 |
Pharmacokinetic Data
| Parameter | Value | Units | Species |
|---|---|---|---|
| AUC | 533.0 | ng.hr.mL-1 | Mus musculus |
| AUC | 1740.0 | ng.hr.mL-1 | Mus musculus |
| CL | 38.0 | mL.min-1.kg-1 | Mus musculus |
| Cmax | 520.01 | nM | Mus musculus |
| F | 15.0 | % | Mus musculus |
| T1/2 | 2.43 | hr | Mus musculus |
| T1/2 | 0.65 | hr | Mus musculus |
| Tmax | 0.25 | hr | Mus musculus |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| PBMC | IC50 | = | 33.0 | nM | 7.48 | Antiinflammatory activity in human PBMCs assessed as inhibition of LPS-induced I... | 23411072 |
| PBMC | IC50 | = | 41.0 | nM | 7.39 | Antiinflammatory activity in human PBMCs assessed as inhibition of LPS-induced T... | 23411072 |
| PBMC | IC50 | = | 43.0 | nM | 7.37 | Antiinflammatory activity in human PBMCs assessed as inhibition of LPS-induced I... | 23411072 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 23411072 | 10.1016/j.bmcl.2013.01.072 | Mus musculus | 9 |
| 23411072 | 10.1016/j.bmcl.2013.01.072 | PBMC | 6 |
Data from ChEMBL 36 via Core Engine