Compound Detail
CHEMBL3546188
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Basic Information
| ChEMBL ID | CHEMBL3546188 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | TUWUQFIFQVYZSK-UHFFFAOYSA-N |
2
Targets
2
Activities
1
Assay Types
0
PK Parameters
2
Publications
0
Known Names
Molecular Properties
273.1
MW (Da)
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 2 meas. best 6.27
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Rho-associated protein kinase 2 CHEMBL2973 | IC50 | 6.27 | 6.27 | 540.0 | 1 |
| Rho-associated protein kinase 1 CHEMBL3231 | IC50 | 6.09 | 6.09 | 810.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Rho-associated protein kinase 2 | IC50 | = | 540.0 | nM | 6.27 | Inhibition of GST-tagged ROCK2 (5 to 554 residues) (unknown origin) using S6-pep... | 26486225 |
| Rho-associated protein kinase 1 | IC50 | = | 810.0 | nM | 6.09 | Inhibition of GST-tagged ROCK1 (1 to 535 residues) (unknown origin) using S6-pep... | 26486225 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 26486225 | 10.1021/acs.jmedchem.5b00683 | Rho-associated protein kinase 1 | 1 |
| 26486225 | 10.1021/acs.jmedchem.5b00683 | Rho-associated protein kinase 2 | 1 |
Data from ChEMBL 36 via Core Engine