Assay Detail
Functional
CHEMBL2345491
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiviral activity against NNRTI-resistant Human immunodeficiency virus 1 harboring reverse transcriptase K103N mutation infected in human TZM-bl cells assessed decrease in p24 level after 7 days by ELISA
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Human immunodeficiency virus 1 |
| Cell Type | TZM-bl |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Target
Human immunodeficiency virus 1 (CHEMBL378) ↗| Type | ORGANISM |
| Organism | Human immunodeficiency virus 1 |
Publication
Novel pyridinone derivatives as non-nucleoside reverse transcriptase inhibitors (NNRTIs) with high potency against NNRTI-resistant HIV-1 strains.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 4 | 7.06 | 7.12 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2337416 | — | — | 1 | 7.12 |
| CHEMBL2337436 | — | — | 1 | 7.00 |
| CHEMBL436546 | — | — | 1 | - |
| CHEMBL57 | NEVIRAPINE | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2337416 | — | EC50 | = | 75.0 | nM | 7.12 |
| CHEMBL2337436 | — | EC50 | = | 100.0 | nM | 7.00 |
| CHEMBL436546 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL57 | NEVIRAPINE | EC50 | > | 10000.0 | nM | - |