Assay Detail
Functional
CHEMBL2345499
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiviral activity against Human immunodeficiency virus 1 SF33 infected in human TZM-bl cells assessed decrease in p24 level after 7 days by ELISA
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Human immunodeficiency virus 1 |
| Cell Type | TZM-bl |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Target
Human immunodeficiency virus 1 (CHEMBL378) ↗| Type | ORGANISM |
| Organism | Human immunodeficiency virus 1 |
Publication
Novel pyridinone derivatives as non-nucleoside reverse transcriptase inhibitors (NNRTIs) with high potency against NNRTI-resistant HIV-1 strains.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 11 | 7.44 | 8.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2337432 | — | — | 1 | 8.30 |
| CHEMBL2337416 | — | — | 1 | 8.05 |
| CHEMBL436546 | — | — | 1 | 7.66 |
| CHEMBL2337431 | — | — | 1 | 7.64 |
| CHEMBL2337430 | — | — | 1 | 7.58 |
| CHEMBL2337437 | — | — | 1 | 7.44 |
| CHEMBL2337436 | — | — | 1 | 7.28 |
| CHEMBL2337433 | — | — | 1 | 7.24 |
| CHEMBL2337435 | — | — | 1 | 7.04 |
| CHEMBL2337438 | — | — | 1 | 6.87 |
| CHEMBL57 | NEVIRAPINE | 4.0 | 1 | 6.72 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2337432 | — | EC50 | = | 5.0 | nM | 8.30 |
| CHEMBL2337416 | — | EC50 | = | 9.0 | nM | 8.05 |
| CHEMBL436546 | — | EC50 | = | 22.0 | nM | 7.66 |
| CHEMBL2337431 | — | EC50 | = | 23.0 | nM | 7.64 |
| CHEMBL2337430 | — | EC50 | = | 26.0 | nM | 7.58 |
| CHEMBL2337437 | — | EC50 | = | 36.0 | nM | 7.44 |
| CHEMBL2337436 | — | EC50 | = | 53.0 | nM | 7.28 |
| CHEMBL2337433 | — | EC50 | = | 57.0 | nM | 7.24 |
| CHEMBL2337435 | — | EC50 | = | 92.0 | nM | 7.04 |
| CHEMBL2337438 | — | EC50 | = | 136.0 | nM | 6.87 |
| CHEMBL57 | NEVIRAPINE | EC50 | = | 190.0 | nM | 6.72 |