Assay Detail
Binding
CHEMBL2345605
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human recombinant ADAMTS5 expressed in HEK293 cells using Abz-TESEwSRGAIY-Dpa-KK as substrate measured for 2 hrs by fluorometric analysis
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HEK293 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
A disintegrin and metalloproteinase with thrombospondin motifs 5 (CHEMBL2285) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Arylsulfonamide inhibitors of aggrecanases as potential therapeutic agents for osteoarthritis: synthesis and biological evaluation.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 6.31 | 7.77 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL24398 | — | — | 1 | 7.77 |
| CHEMBL2337698 | — | — | 1 | 7.46 |
| CHEMBL198778 | — | — | 1 | 6.48 |
| CHEMBL19611 | ILOMASTAT | 2.0 | 1 | 6.30 |
| CHEMBL2337691 | — | — | 1 | 6.21 |
| CHEMBL2337696 | — | — | 1 | 5.85 |
| CHEMBL2337690 | — | — | 1 | 5.75 |
| CHEMBL197842 | — | — | 1 | 5.47 |
| CHEMBL2337697 | — | — | 1 | 5.46 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL24398 | — | IC50 | = | 17.0 | nM | 7.77 |
| CHEMBL2337698 | — | IC50 | = | 35.0 | nM | 7.46 |
| CHEMBL198778 | — | IC50 | = | 330.0 | nM | 6.48 |
| CHEMBL19611 | ILOMASTAT | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL2337691 | — | IC50 | = | 620.0 | nM | 6.21 |
| CHEMBL2337696 | — | IC50 | = | 1410.0 | nM | 5.85 |
| CHEMBL2337690 | — | IC50 | = | 1770.0 | nM | 5.75 |
| CHEMBL197842 | — | IC50 | = | 3400.0 | nM | 5.47 |
| CHEMBL2337697 | — | IC50 | = | 3500.0 | nM | 5.46 |