A disintegrin and metalloproteinase with thrombospondin motifs 5 · SINGLE PROTEIN · Homo sapiens
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As of 2026-09-14A disintegrin and metalloproteinase with thrombospondin motifs 5 shows clinical signal disease relevance led by osteoarthritis. 1 linked drug keeps the current disease frame grounded. Protein identity stays anchored to UniProt Q9UNA0. Start with osteoarthritis, then reuse UniProt Q9UNA0 as the stable protein anchor across project notes and exports.
Start with osteoarthritis, then reuse UniProt Q9UNA0 as the stable protein anchor across project notes and exports.
A disintegrin and metalloproteinase with thrombospondin motifs 5 shows clinical signal disease relevance led by osteoarthritis. 1 linked drug remains visible in the same block.
Start review with osteoarthritis because it currently carries clinical signal support. Linked drugs include ALDUMASTAT. This disease block keeps the Open Targets-ready contract explicit while current evidence comes from ChEMBL mechanism and indication mappings.
Disease source · ChEMBL drug mechanism + indication proxyA disintegrin and metalloproteinase with thrombospondin motifs 5
Review this target as A disintegrin and metalloproteinase with thrombospondin motifs 5, mapped to UniProt Q9UNA0. Sequence length is 930 aa.
Protein source · UniProt accession via ChEMBL component mappingKeep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats A disintegrin and metalloproteinase with thrombospondin motifs 5 as ChEMBL target CHEMBL2285, mapped to UniProt Q9UNA0. Disease framing currently uses the Open Targets-ready proxy contract.
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Start here when your first question is whether A disintegrin and metalloproteinase with thrombospondin motifs 5 is the right protein anchor across sources, using UniProt Q9UNA0 as the stable mapping.
Jump to Protein ContextUse this block first when you need to confirm why osteoarthritis is currently framed as clinical signal support. It currently carries 1 linked drug in the same disease frame.
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| Preferred Name | A disintegrin and metalloproteinase with thrombospondin motifs 5 |
| Target Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
| UniProt | Q9UNA0 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | A disintegrin and metalloproteinase with thrombospondin motifs 5 |
| UniProt Accession | Q9UNA0 |
| Component Type | Protein |
| Sequence Length | 930 aa |
A disintegrin and metalloproteinase with thrombospondin motifs 5
Review this target as A disintegrin and metalloproteinase with thrombospondin motifs 5, mapped to UniProt Q9UNA0. Sequence length is 930 aa.
Open Targets-ready disease context using the current target-indication evidence contract.
A disintegrin and metalloproteinase with thrombospondin motifs 5 shows clinical signal disease relevance led by osteoarthritis.
Start review with osteoarthritis because it currently carries clinical signal support. Linked drugs include ALDUMASTAT. This disease block keeps the Open Targets-ready contract explicit while current evidence comes from ChEMBL mechanism and indication mappings.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL187092 | 9.0 | IC50 | 1.0 | Preclinical |
| CHEMBL4066965 | 9.0 | IC50 | 1.0 | Preclinical |
| CHEMBL179552 | 8.85 | IC50 | 1.4 | Preclinical |
| CHEMBL3980860 | 8.7 | IC50 | 2.0 | Preclinical |
| CHEMBL4072836 | 8.7 | IC50 | 2.0 | Preclinical |
| CHEMBL1766903 | 8.54 | IC50 | 2.9 | Preclinical |
| CHEMBL3358156 | 8.52 | IC50 | 3.0 | Preclinical |
| CHEMBL4436740 | 8.52 | IC50 | 3.0 | Preclinical |
| CHEMBL5589746 | 8.52 | Ki | 3.0 | Preclinical |
| CHEMBL5595366 | 8.52 | Ki | 3.0 | Preclinical |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| single protein format | 63 | 920 | 6.7 |
| cell-based format | 7 | 51 | 6.3 |
| assay format | 1 | 7 | 6.9 |
| cell-free format | 1 | 8 | 7.0 |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| assay format | 1 | 12 | 7.1 |