Assay Detail
Binding
CHEMBL2345676
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Inhibition of AChE (unknown origin) using acetylthiocholine iodide substrate by Ellman's method based spectrophotometry
34
Total Activities
34
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Synthesis and discovery of novel piperidone-grafted mono- and bis-spirooxindole-hexahydropyrrolizines as potent cholinesterase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 34 | 4.88 | 5.68 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL659 | GALANTAMINE | 4.0 | 1 | 5.68 |
| CHEMBL2332979 | — | — | 1 | 5.47 |
| CHEMBL2332977 | — | — | 1 | 5.39 |
| CHEMBL2332976 | — | — | 1 | 5.22 |
| CHEMBL2332545 | — | — | 1 | 5.17 |
| CHEMBL2332531 | — | — | 1 | 5.16 |
| CHEMBL2332541 | — | — | 1 | 5.10 |
| CHEMBL2332539 | — | — | 1 | 5.06 |
| CHEMBL2332537 | — | — | 1 | 5.01 |
| CHEMBL2332542 | — | — | 1 | 4.94 |
| CHEMBL2332536 | — | — | 1 | 4.93 |
| CHEMBL2332974 | — | — | 1 | 4.92 |
| CHEMBL2332549 | — | — | 1 | 4.90 |
| CHEMBL2332534 | — | — | 1 | 4.87 |
| CHEMBL2332547 | — | — | 1 | 4.86 |
| CHEMBL350032 | — | — | 1 | 4.82 |
| CHEMBL2332546 | — | — | 1 | 4.80 |
| CHEMBL2332550 | — | — | 1 | 4.80 |
| CHEMBL2332535 | — | — | 1 | 4.79 |
| CHEMBL2332548 | — | — | 1 | 4.76 |
| CHEMBL2332538 | — | — | 1 | 4.76 |
| CHEMBL156016 | — | — | 1 | 4.75 |
| CHEMBL454594 | — | — | 1 | 4.74 |
| CHEMBL2332544 | — | — | 1 | 4.71 |
| CHEMBL2332530 | — | — | 1 | 4.71 |
| CHEMBL2332978 | — | — | 1 | 4.70 |
| CHEMBL2332980 | — | — | 1 | 4.70 |
| CHEMBL2332981 | — | — | 1 | 4.69 |
| CHEMBL152675 | — | — | 1 | 4.66 |
| CHEMBL2332540 | — | — | 1 | 4.63 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL659 | GALANTAMINE | IC50 | = | 2090.0 | nM | 5.68 |
| CHEMBL2332979 | — | IC50 | = | 3360.0 | nM | 5.47 |
| CHEMBL2332977 | — | IC50 | = | 4110.0 | nM | 5.39 |
| CHEMBL2332976 | — | IC50 | = | 5990.0 | nM | 5.22 |
| CHEMBL2332545 | — | IC50 | = | 6760.0 | nM | 5.17 |
| CHEMBL2332531 | — | IC50 | = | 6960.0 | nM | 5.16 |
| CHEMBL2332541 | — | IC50 | = | 7920.0 | nM | 5.10 |
| CHEMBL2332539 | — | IC50 | = | 8720.0 | nM | 5.06 |
| CHEMBL2332537 | — | IC50 | = | 9760.0 | nM | 5.01 |
| CHEMBL2332542 | — | IC50 | = | 11410.0 | nM | 4.94 |
| CHEMBL2332536 | — | IC50 | = | 11810.0 | nM | 4.93 |
| CHEMBL2332974 | — | IC50 | = | 11920.0 | nM | 4.92 |
| CHEMBL2332549 | — | IC50 | = | 12470.0 | nM | 4.90 |
| CHEMBL2332534 | — | IC50 | = | 13640.0 | nM | 4.87 |
| CHEMBL2332547 | — | IC50 | = | 13840.0 | nM | 4.86 |
| CHEMBL350032 | — | IC50 | = | 15120.0 | nM | 4.82 |
| CHEMBL2332550 | — | IC50 | = | 15860.0 | nM | 4.80 |
| CHEMBL2332546 | — | IC50 | = | 15750.0 | nM | 4.80 |
| CHEMBL2332535 | — | IC50 | = | 16320.0 | nM | 4.79 |
| CHEMBL2332548 | — | IC50 | = | 17490.0 | nM | 4.76 |
| CHEMBL2332538 | — | IC50 | = | 17390.0 | nM | 4.76 |
| CHEMBL156016 | — | IC50 | = | 17680.0 | nM | 4.75 |
| CHEMBL454594 | — | IC50 | = | 18060.0 | nM | 4.74 |
| CHEMBL2332544 | — | IC50 | = | 19650.0 | nM | 4.71 |
| CHEMBL2332530 | — | IC50 | = | 19590.0 | nM | 4.71 |
| CHEMBL2332978 | — | IC50 | = | 20070.0 | nM | 4.70 |
| CHEMBL2332980 | — | IC50 | = | 19840.0 | nM | 4.70 |
| CHEMBL2332981 | — | IC50 | = | 20630.0 | nM | 4.69 |
| CHEMBL152675 | — | IC50 | = | 22040.0 | nM | 4.66 |
| CHEMBL2332540 | — | IC50 | = | 23670.0 | nM | 4.63 |
| CHEMBL2332533 | — | IC50 | = | 24580.0 | nM | 4.61 |
| CHEMBL2332532 | — | IC50 | = | 26600.0 | nM | 4.58 |
| CHEMBL2332543 | — | IC50 | = | 27450.0 | nM | 4.56 |
| CHEMBL2332975 | — | IC50 | = | 34370.0 | nM | 4.46 |