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Assay Detail

CHEMBL2345680

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Cytotoxicity against human HL60 cells assessed as cell viability after 72 hrs by MTT assay
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Cell Type HL-60
Confidence 1 — Organism
Curated By Autocuration

Target

HL-60 (CHEMBL383)
Type CELL-LINE
Organism Homo sapiens

Publication

Annulation of substituted anthracene-9,10-diones yields promising selectively antiproliferative compounds.
Castro-Castillo V, Suárez-Rozas C, Castro-Loiza N, Theoduloz C, Cassels BK.
Eur J Med Chem (2013) 62 : 688 -692
PubMed 23454511 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 12 4.99 5.75

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL44657 ETOPOSIDE 4.0 1 5.75
CHEMBL2332990 1 5.39
CHEMBL2332984 1 4.71
CHEMBL2332982 1 4.65
CHEMBL2332988 1 4.45
CHEMBL2332989 1 -
CHEMBL2332987 1 -
CHEMBL2332986 1 -
CHEMBL52884 1 -
CHEMBL451977 1 -
CHEMBL2332985 2-METHOXYANTHRAQUINONE 1 -
CHEMBL55659 ANTHRAQUINONE 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL44657 ETOPOSIDE IC50 = 1800.0 nM 5.75
CHEMBL2332990 IC50 = 4100.0 nM 5.39
CHEMBL2332984 IC50 = 19500.0 nM 4.71
CHEMBL2332982 IC50 = 22200.0 nM 4.65
CHEMBL2332988 IC50 = 35600.0 nM 4.45
CHEMBL2332989 IC50 > 100000.0 nM -
CHEMBL2332987 IC50 > 100000.0 nM -
CHEMBL2332986 IC50 > 100000.0 nM -
CHEMBL52884 IC50 > 100000.0 nM -
CHEMBL451977 IC50 > 100000.0 nM -
CHEMBL2332985 2-METHOXYANTHRAQUINONE IC50 > 100000.0 nM -
CHEMBL55659 ANTHRAQUINONE IC50 > 100000.0 nM -