Assay Detail
Functional
CHEMBL2345824
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Cytotoxicity against human ES2 cells after 24 hrs by XTT assay
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | ES2 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
The structure of anthracycline derivatives determines their subcellular localization and cytotoxic activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 5.00 | 5.50 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1117 | IDARUBICIN | 4.0 | 1 | 5.50 |
| CHEMBL2022407 | — | — | 1 | 5.17 |
| CHEMBL2331656 | — | — | 1 | 4.75 |
| CHEMBL178 | DAUNORUBICIN | 4.0 | 1 | 4.59 |
| CHEMBL53463 | DOXORUBICIN | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1117 | IDARUBICIN | IC50 | = | 3200.0 | nM | 5.50 |
| CHEMBL2022407 | — | IC50 | = | 6800.0 | nM | 5.17 |
| CHEMBL2331656 | — | IC50 | = | 17700.0 | nM | 4.75 |
| CHEMBL178 | DAUNORUBICIN | IC50 | = | 25500.0 | nM | 4.59 |
| CHEMBL53463 | DOXORUBICIN | IC50 | > | 60000.0 | nM | - |