Assay Detail
Functional
CHEMBL2345933
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiplatelet activity against collagen collagen-induced platelet aggregation in human plasma preincubated for 2 mins before addition of inducer by turbidimetric method
21
Total Activities
21
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Tissue | Plasma |
| Cell Type | Platelet |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Synthesis, in vitro antiplatelet activity and molecular modelling studies of 10-substituted 2-(1-piperazinyl)pyrimido[1,2-a]benzimidazol-4(10H)-ones.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 21 | 4.58 | 5.10 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2336443 | — | — | 1 | 5.10 |
| CHEMBL229956 | — | — | 1 | 5.06 |
| CHEMBL2336440 | — | — | 1 | 5.05 |
| CHEMBL189 | MILRINONE | 4.0 | 1 | 4.92 |
| CHEMBL2336444 | — | — | 1 | 4.89 |
| CHEMBL2336437 | — | — | 1 | 4.82 |
| CHEMBL2336446 | — | — | 1 | 4.82 |
| CHEMBL2336441 | — | — | 1 | 4.68 |
| CHEMBL2336435 | — | — | 1 | 4.57 |
| CHEMBL2336445 | — | — | 1 | 4.55 |
| CHEMBL2336439 | — | — | 1 | 4.52 |
| CHEMBL2336438 | — | — | 1 | 4.51 |
| CHEMBL799 | CILOSTAZOL | 4.0 | 1 | 4.40 |
| CHEMBL2336442 | — | — | 1 | 4.31 |
| CHEMBL2336450 | — | — | 1 | 4.30 |
| CHEMBL2336449 | — | — | 1 | 4.26 |
| CHEMBL2336447 | — | — | 1 | 4.12 |
| CHEMBL2336448 | — | — | 1 | 4.12 |
| CHEMBL2336451 | — | — | 1 | 4.11 |
| CHEMBL25 | ASPIRIN | 4.0 | 1 | - |
| CHEMBL2336436 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2336443 | — | IC50 | = | 8000.0 | nM | 5.10 |
| CHEMBL229956 | — | IC50 | = | 8800.0 | nM | 5.06 |
| CHEMBL2336440 | — | IC50 | = | 9000.0 | nM | 5.05 |
| CHEMBL189 | MILRINONE | IC50 | = | 12000.0 | nM | 4.92 |
| CHEMBL2336444 | — | IC50 | = | 13000.0 | nM | 4.89 |
| CHEMBL2336437 | — | IC50 | = | 15000.0 | nM | 4.82 |
| CHEMBL2336446 | — | IC50 | = | 15000.0 | nM | 4.82 |
| CHEMBL2336441 | — | IC50 | = | 21000.0 | nM | 4.68 |
| CHEMBL2336435 | — | IC50 | = | 27000.0 | nM | 4.57 |
| CHEMBL2336445 | — | IC50 | = | 28000.0 | nM | 4.55 |
| CHEMBL2336439 | — | IC50 | = | 30000.0 | nM | 4.52 |
| CHEMBL2336438 | — | IC50 | = | 31000.0 | nM | 4.51 |
| CHEMBL799 | CILOSTAZOL | IC50 | = | 40000.0 | nM | 4.40 |
| CHEMBL2336442 | — | IC50 | = | 49000.0 | nM | 4.31 |
| CHEMBL2336450 | — | IC50 | = | 50000.0 | nM | 4.30 |
| CHEMBL2336449 | — | IC50 | = | 55000.0 | nM | 4.26 |
| CHEMBL2336447 | — | IC50 | = | 75000.0 | nM | 4.12 |
| CHEMBL2336448 | — | IC50 | = | 75000.0 | nM | 4.12 |
| CHEMBL2336451 | — | IC50 | = | 77000.0 | nM | 4.11 |
| CHEMBL25 | ASPIRIN | IC50 | = | 183000.0 | nM | - |
| CHEMBL2336436 | — | IC50 | = | 172000.0 | nM | - |