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Assay Detail

CHEMBL2345934

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Functional
Antiplatelet activity against collagen ADP-induced platelet aggregation in human plasma preincubated for 2 mins before addition of inducer by turbidimetric method
21
Total Activities
21
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Tissue Plasma
Cell Type Platelet
Confidence 1 — Organism
Curated By Autocuration

Publication

Synthesis, in vitro antiplatelet activity and molecular modelling studies of 10-substituted 2-(1-piperazinyl)pyrimido[1,2-a]benzimidazol-4(10H)-ones.
Di Braccio M, Grossi G, Signorello MG, Leoncini G, Cichero E, Fossa P, Alfei S, Damonte G.
Eur J Med Chem (2013) 62 : 564 -578
PubMed 23425969 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 21 4.63 5.44

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL229956 1 5.44
CHEMBL189 MILRINONE 4.0 1 4.96
CHEMBL2336446 1 4.92
CHEMBL2336441 1 4.82
CHEMBL2336440 1 4.82
CHEMBL2336445 1 4.80
CHEMBL2336444 1 4.80
CHEMBL2336439 1 4.72
CHEMBL2336438 1 4.58
CHEMBL2336442 1 4.48
CHEMBL2336443 1 4.44
CHEMBL2336437 1 4.28
CHEMBL2336450 1 4.21
CHEMBL799 CILOSTAZOL 4.0 1 4.14
CHEMBL2336435 1 4.05
CHEMBL2336447 1 -
CHEMBL2336448 1 -
CHEMBL25 ASPIRIN 4.0 1 -
CHEMBL2336436 1 -
CHEMBL2336451 1 -
CHEMBL2336449 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL229956 IC50 = 3600.0 nM 5.44
CHEMBL189 MILRINONE IC50 = 11000.0 nM 4.96
CHEMBL2336446 IC50 = 12000.0 nM 4.92
CHEMBL2336441 IC50 = 15000.0 nM 4.82
CHEMBL2336440 IC50 = 15000.0 nM 4.82
CHEMBL2336445 IC50 = 16000.0 nM 4.80
CHEMBL2336444 IC50 = 16000.0 nM 4.80
CHEMBL2336439 IC50 = 19000.0 nM 4.72
CHEMBL2336438 IC50 = 26000.0 nM 4.58
CHEMBL2336442 IC50 = 33000.0 nM 4.48
CHEMBL2336443 IC50 = 36000.0 nM 4.44
CHEMBL2336437 IC50 = 53000.0 nM 4.28
CHEMBL2336450 IC50 = 62000.0 nM 4.21
CHEMBL799 CILOSTAZOL IC50 = 73000.0 nM 4.14
CHEMBL2336435 IC50 = 90000.0 nM 4.05
CHEMBL2336447 IC50 > 1000000.0 nM -
CHEMBL2336448 IC50 > 1000000.0 nM -
CHEMBL25 ASPIRIN IC50 > 1000000.0 nM -
CHEMBL2336436 IC50 = 163000.0 nM -
CHEMBL2336451 IC50 = 116000.0 nM -
CHEMBL2336449 IC50 = 127000.0 nM -