Assay Detail
Binding
CHEMBL2346132
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human DPP4 using H-Gly-Pro-AMC as substrate preincubated for 10 mins prior to substrate addition by fluorescence assay
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Identification of selective and potent inhibitors of fibroblast activation protein and prolyl oligopeptidase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 7.06 | 9.05 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL67279 | TALABOSTAT | 3.0 | 1 | 9.05 |
| CHEMBL67089 | — | — | 1 | 7.89 |
| CHEMBL2333023 | — | — | 1 | 5.75 |
| CHEMBL2333025 | — | — | 1 | 5.55 |
| CHEMBL2333024 | — | — | 1 | - |
| CHEMBL2333026 | — | — | 1 | - |
| CHEMBL1243373 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL67279 | TALABOSTAT | IC50 | = | 0.9 | nM | 9.05 |
| CHEMBL67089 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL2333023 | — | IC50 | = | 1800.0 | nM | 5.75 |
| CHEMBL2333025 | — | IC50 | = | 2800.0 | nM | 5.55 |
| CHEMBL2333024 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL2333026 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL1243373 | — | IC50 | > | 100000.0 | nM | - |