Compound Detail
CHEMBL2333025
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Basic Information
| ChEMBL ID | CHEMBL2333025 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | NFLFYUMFQNNIPE-JTQLQIEISA-N |
5
Targets
5
Activities
1
Assay Types
0
PK Parameters
6
Publications
0
Known Names
Molecular Properties
277.1
MW (Da)
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 5 meas. best 9.33
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Prolyl endopeptidase FAP CHEMBL4683 | IC50 | 9.33 | 9.33 | 0.5 | 1 |
| Prolyl endopeptidase CHEMBL3202 | IC50 | 8.3 | 8.3 | 5.0 | 1 |
| Dipeptidyl peptidase 9 CHEMBL4793 | IC50 | 6.0 | 6.0 | 1000.0 | 1 |
| Dipeptidyl peptidase 8 CHEMBL4657 | IC50 | 5.72 | 5.72 | 1900.0 | 1 |
| Dipeptidyl peptidase 4 CHEMBL284 | IC50 | 5.55 | 5.55 | 2800.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Prolyl endopeptidase FAP | IC50 | = | 0.47 | nM | 9.33 | Inhibition of human FAP using Z-Gly-Pro-AMC as substrate preincubated for 10 min... | 23594271 |
| Prolyl endopeptidase | IC50 | = | 5.0 | nM | 8.3 | Inhibition of human PREP using Z-Gly-Pro-AMC as substrate preincubated for 10 mi... | 23594271 |
| Dipeptidyl peptidase 9 | IC50 | = | 1000.0 | nM | 6.0 | Inhibition of human DPP9 using H-Gly-Pro-AMC as substrate preincubated for 10 mi... | 23594271 |
| Dipeptidyl peptidase 8 | IC50 | = | 1900.0 | nM | 5.72 | Inhibition of human DPP8 using H-Gly-Pro-AMC as substrate preincubated for 10 mi... | 23594271 |
| Dipeptidyl peptidase 4 | IC50 | = | 2800.0 | nM | 5.55 | Inhibition of human DPP4 using H-Gly-Pro-AMC as substrate preincubated for 10 mi... | 23594271 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 23594271 | 10.1021/jm400351a | Prolyl endopeptidase | 1 |
| 23594271 | 10.1021/jm400351a | Prolyl endopeptidase FAP | 1 |
| 23594271 | 10.1021/jm400351a | Dipeptidyl peptidase 9 | 1 |
| 23594271 | 10.1021/jm400351a | Dipeptidyl peptidase 8 | 1 |
| 23594271 | 10.1021/jm400351a | Dipeptidyl peptidase 4 | 1 |
| 23594271 | 10.1021/jm400351a | Unchecked | 1 |
Data from ChEMBL 36 via Core Engine