Assay Detail
Binding
CHEMBL2346137
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of rat recombinant acid ceramidase expressed in human HEK293 cells using N-lauroylceramide as substrate incubated for 30 mins prior to substrate addition measured after 30 mins by LC/MS analysis
37
Total Activities
37
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Cell Type | HEK293 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Discovery of a new class of highly potent inhibitors of acid ceramidase: synthesis and structure-activity relationship (SAR).
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 37 | 6.88 | 8.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2333064 | — | — | 1 | 8.40 |
| CHEMBL2333062 | — | — | 1 | 8.15 |
| CHEMBL2333053 | — | — | 1 | 8.15 |
| CHEMBL2333033 | — | — | 1 | 7.92 |
| CHEMBL2333054 | — | — | 1 | 7.92 |
| CHEMBL2333048 | — | — | 1 | 7.89 |
| CHEMBL2333055 | — | — | 1 | 7.80 |
| CHEMBL2333050 | — | — | 1 | 7.75 |
| CHEMBL2333056 | — | — | 1 | 7.70 |
| CHEMBL2333052 | — | — | 1 | 7.68 |
| CHEMBL460499 | CARMOFUR | 2.0 | 1 | 7.54 |
| CHEMBL2333060 | — | — | 1 | 7.34 |
| CHEMBL2333042 | — | — | 1 | 7.29 |
| CHEMBL2333049 | — | — | 1 | 7.28 |
| CHEMBL2333051 | — | — | 1 | 7.21 |
| CHEMBL2333032 | — | — | 1 | 7.17 |
| CHEMBL2333041 | — | — | 1 | 6.83 |
| CHEMBL2333040 | — | — | 1 | 6.75 |
| CHEMBL2333061 | — | — | 1 | 6.55 |
| CHEMBL2333059 | — | — | 1 | 6.49 |
| CHEMBL2333035 | — | — | 1 | 6.38 |
| CHEMBL2333065 | — | — | 1 | 6.37 |
| CHEMBL2333063 | — | — | 1 | 6.33 |
| CHEMBL2333034 | — | — | 1 | 6.13 |
| CHEMBL2333038 | — | — | 1 | 6.06 |
| CHEMBL2333036 | — | — | 1 | 5.96 |
| CHEMBL2333039 | — | — | 1 | 5.85 |
| CHEMBL2333031 | — | — | 1 | 5.84 |
| CHEMBL2333058 | — | — | 1 | 5.68 |
| CHEMBL2333044 | — | — | 1 | 5.47 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2333064 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL2333062 | — | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL2333053 | — | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL2333033 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL2333054 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL2333048 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL2333055 | — | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL2333050 | — | IC50 | = | 18.0 | nM | 7.75 |
| CHEMBL2333056 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL2333052 | — | IC50 | = | 21.0 | nM | 7.68 |
| CHEMBL460499 | CARMOFUR | IC50 | = | 29.0 | nM | 7.54 |
| CHEMBL2333060 | — | IC50 | = | 46.0 | nM | 7.34 |
| CHEMBL2333042 | — | IC50 | = | 51.0 | nM | 7.29 |
| CHEMBL2333049 | — | IC50 | = | 53.0 | nM | 7.28 |
| CHEMBL2333051 | — | IC50 | = | 61.0 | nM | 7.21 |
| CHEMBL2333032 | — | IC50 | = | 67.0 | nM | 7.17 |
| CHEMBL2333041 | — | IC50 | = | 147.0 | nM | 6.83 |
| CHEMBL2333040 | — | IC50 | = | 177.0 | nM | 6.75 |
| CHEMBL2333061 | — | IC50 | = | 283.0 | nM | 6.55 |
| CHEMBL2333059 | — | IC50 | = | 325.0 | nM | 6.49 |
| CHEMBL2333035 | — | IC50 | = | 417.0 | nM | 6.38 |
| CHEMBL2333065 | — | IC50 | = | 426.0 | nM | 6.37 |
| CHEMBL2333063 | — | IC50 | = | 464.0 | nM | 6.33 |
| CHEMBL2333034 | — | IC50 | = | 733.0 | nM | 6.13 |
| CHEMBL2333038 | — | IC50 | = | 875.0 | nM | 6.06 |
| CHEMBL2333036 | — | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL2333039 | — | IC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL2333031 | — | IC50 | = | 1460.0 | nM | 5.84 |
| CHEMBL2333058 | — | IC50 | = | 2100.0 | nM | 5.68 |
| CHEMBL2333044 | — | IC50 | = | 3400.0 | nM | 5.47 |
| CHEMBL2333037 | — | IC50 | = | 5500.0 | nM | 5.26 |
| CHEMBL2333057 | — | IC50 | = | 8500.0 | nM | 5.07 |
| CHEMBL2333043 | — | IC50 | - | — | - | |
| CHEMBL2333045 | — | IC50 | - | — | - | |
| CHEMBL2333046 | — | IC50 | - | — | - | |
| CHEMBL2333047 | — | IC50 | - | — | - | |
| CHEMBL2331572 | — | IC50 | - | — | - |