Assay Detail
Functional
CHEMBL2346159
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Inhibition of Pre-mRNA splicing in human HEK293 cells using p32-labeled CDC14-15 pre-mRNA by exonjunction complex (EJC) immunoprecipitation assay
5
Total Activities
4
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HEK293 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Genomics-guided discovery of thailanstatins A, B, and C As pre-mRNA splicing inhibitors and antiproliferative agents from Burkholderia thailandensis MSMB43.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 5.70 | 6.24 |
| Inhibition | 1 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL494107 | — | — | 2 | 6.24 |
| CHEMBL2333561 | THAILANSTATIN A | — | 1 | 6.19 |
| CHEMBL2333560 | THAILANSTATIN B | — | 1 | 5.21 |
| CHEMBL2331577 | THAILANSTATIN C | — | 1 | 5.17 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL494107 | — | IC50 | = | 580.0 | nM | 6.24 |
| CHEMBL2333561 | THAILANSTATIN A | IC50 | = | 650.0 | nM | 6.19 |
| CHEMBL2333560 | THAILANSTATIN B | IC50 | = | 6180.0 | nM | 5.21 |
| CHEMBL2331577 | THAILANSTATIN C | IC50 | = | 6840.0 | nM | 5.17 |
| CHEMBL494107 | — | Inhibition | - | % | - |