Assay Detail
Binding
CHEMBL2346384
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of NIK (unknown origin) autophosphorylation after 1 hr by chemiluminescent assay
31
Total Activities
31
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Mitogen-activated protein kinase kinase kinase 14 (CHEMBL5888) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Inhibiting NF-κB-inducing kinase (NIK): discovery, structure-based design, synthesis, structure-activity relationship, and co-crystal structures.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 31 | 5.97 | 7.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2334589 | — | — | 1 | 7.40 |
| CHEMBL2334586 | — | — | 1 | 7.39 |
| CHEMBL2334970 | — | — | 1 | 7.20 |
| CHEMBL2334966 | — | — | 1 | 7.20 |
| CHEMBL2334579 | — | — | 1 | 7.16 |
| CHEMBL2334964 | — | — | 1 | 7.12 |
| CHEMBL2334965 | — | — | 1 | 7.05 |
| CHEMBL2334583 | — | — | 1 | 7.00 |
| CHEMBL2334577 | — | — | 1 | 6.96 |
| CHEMBL2334963 | — | — | 1 | 6.82 |
| CHEMBL2334591 | — | — | 1 | 6.72 |
| CHEMBL2334962 | — | — | 1 | 6.52 |
| CHEMBL2334593 | — | — | 1 | 6.51 |
| CHEMBL2334967 | — | — | 1 | 6.26 |
| CHEMBL2334590 | — | — | 1 | 6.22 |
| CHEMBL2334581 | — | — | 1 | 5.92 |
| CHEMBL2334968 | — | — | 1 | 5.75 |
| CHEMBL2334580 | — | — | 1 | 5.58 |
| CHEMBL2334592 | — | — | 1 | 5.40 |
| CHEMBL2334588 | — | — | 1 | 4.82 |
| CHEMBL2334582 | — | — | 1 | 4.68 |
| CHEMBL2334969 | — | — | 1 | 4.62 |
| CHEMBL2334587 | — | — | 1 | 4.62 |
| CHEMBL2334578 | — | — | 1 | 4.52 |
| CHEMBL2334584 | — | — | 1 | 4.52 |
| CHEMBL2334585 | — | — | 1 | 4.52 |
| CHEMBL48082 | — | — | 1 | 4.39 |
| CHEMBL2334971 | — | — | 1 | 4.38 |
| CHEMBL2334575 | — | — | 1 | - |
| CHEMBL2334576 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2334589 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL2334586 | — | IC50 | = | 41.0 | nM | 7.39 |
| CHEMBL2334970 | — | IC50 | = | 63.0 | nM | 7.20 |
| CHEMBL2334966 | — | IC50 | = | 63.0 | nM | 7.20 |
| CHEMBL2334579 | — | IC50 | = | 70.0 | nM | 7.16 |
| CHEMBL2334964 | — | IC50 | = | 76.0 | nM | 7.12 |
| CHEMBL2334965 | — | IC50 | = | 89.0 | nM | 7.05 |
| CHEMBL2334583 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL2334577 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL2334963 | — | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL2334591 | — | IC50 | = | 190.0 | nM | 6.72 |
| CHEMBL2334962 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL2334593 | — | IC50 | = | 310.0 | nM | 6.51 |
| CHEMBL2334967 | — | IC50 | = | 550.0 | nM | 6.26 |
| CHEMBL2334590 | — | IC50 | = | 600.0 | nM | 6.22 |
| CHEMBL2334581 | — | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL2334968 | — | IC50 | = | 1800.0 | nM | 5.75 |
| CHEMBL2334580 | — | IC50 | = | 2600.0 | nM | 5.58 |
| CHEMBL2334592 | — | IC50 | = | 4000.0 | nM | 5.40 |
| CHEMBL2334588 | — | IC50 | = | 15000.0 | nM | 4.82 |
| CHEMBL2334582 | — | IC50 | = | 21000.0 | nM | 4.68 |
| CHEMBL2334969 | — | IC50 | = | 24000.0 | nM | 4.62 |
| CHEMBL2334587 | — | IC50 | = | 24000.0 | nM | 4.62 |
| CHEMBL2334578 | — | IC50 | = | 30000.0 | nM | 4.52 |
| CHEMBL2334584 | — | IC50 | = | 30000.0 | nM | 4.52 |
| CHEMBL2334585 | — | IC50 | = | 30000.0 | nM | 4.52 |
| CHEMBL48082 | — | IC50 | = | 41000.0 | nM | 4.39 |
| CHEMBL2334971 | — | IC50 | = | 42000.0 | nM | 4.38 |
| CHEMBL2334575 | — | IC50 | > | 80000.0 | nM | - |
| CHEMBL2334576 | — | IC50 | > | 80000.0 | nM | - |
| CHEMBL100979 | — | IC50 | > | 80000.0 | nM | - |