Mitogen-activated protein kinase kinase kinase 14 · SINGLE PROTEIN · Homo sapiens
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As of 2026-09-14Protein identity stays anchored to UniProt Q99558. Use UniProt Q99558 as the stable identity anchor, then attach disease evidence before program review.
Use UniProt Q99558 as the stable identity anchor, then attach disease evidence before program review.
Mitogen-activated protein kinase kinase kinase 14
Review this target as Mitogen-activated protein kinase kinase kinase 14, mapped to UniProt Q99558. Sequence length is 947 aa.
Protein source · UniProt accession via ChEMBL component mappingKeep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats Mitogen-activated protein kinase kinase kinase 14 as ChEMBL target CHEMBL5888, mapped to UniProt Q99558. Disease framing currently uses the Open Targets-ready proxy contract.
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| Preferred Name | Mitogen-activated protein kinase kinase kinase 14 |
| Target Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
| UniProt | Q99558 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | Mitogen-activated protein kinase kinase kinase 14 |
| UniProt Accession | Q99558 |
| Component Type | Protein |
| Sequence Length | 947 aa |
Mitogen-activated protein kinase kinase kinase 14
Review this target as Mitogen-activated protein kinase kinase kinase 14, mapped to UniProt Q99558. Sequence length is 947 aa.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL3696534 | 10.4 | Ki | 0.04 | Preclinical |
| CHEMBL4204233 | 10.3 | Ki | 0.05 | Preclinical |
| CHEMBL4205698 | 10.3 | Ki | 0.05 | Preclinical |
| CHEMBL4217407 | 10.3 | Ki | 0.05 | Preclinical |
| CHEMBL5769590 | 10.3 | Ki | 0.05 | Preclinical |
| CHEMBL5796189 | 10.3 | Ki | 0.05 | Preclinical |
| CHEMBL5800378 | 10.3 | Ki | 0.05 | Preclinical |
| CHEMBL5805453 | 10.3 | Ki | 0.05 | Preclinical |
| CHEMBL5824850 | 10.3 | Ki | 0.05 | Preclinical |
| CHEMBL5858445 | 10.3 | Ki | 0.05 | Preclinical |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| single protein format | 94 | 473 | 7.9 |
| cell-based format | 27 | 126 | 6.6 |
| assay format | 22 | 819 | 8.1 |