Assay Detail
ADMET
CHEMBL2350277
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human CYP1A2
10
Total Activities
5
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | ADMET |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Synthesis and evaluation of non-dimeric HCV NS5A inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC90 | 5 | - | - |
| IC50 | 5 | 4.14 | 4.25 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2347337 | — | — | 2 | 4.25 |
| CHEMBL2347323 | — | — | 2 | 4.09 |
| CHEMBL2347328 | — | — | 2 | 4.08 |
| CHEMBL2347159 | — | — | 2 | - |
| CHEMBL2023898 | DACLATASVIR | 4.0 | 2 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2347337 | — | IC50 | = | 56700.0 | nM | 4.25 |
| CHEMBL2347323 | — | IC50 | = | 80900.0 | nM | 4.09 |
| CHEMBL2347328 | — | IC50 | = | 82900.0 | nM | 4.08 |
| CHEMBL2347337 | — | IC90 | > | 100000.0 | nM | - |
| CHEMBL2347328 | — | IC90 | > | 100000.0 | nM | - |
| CHEMBL2347323 | — | IC90 | > | 100000.0 | nM | - |
| CHEMBL2347159 | — | IC90 | > | 100000.0 | nM | - |
| CHEMBL2023898 | DACLATASVIR | IC90 | > | 100000.0 | nM | - |
| CHEMBL2347159 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL2023898 | DACLATASVIR | IC50 | > | 100000.0 | nM | - |