Skip to main content
Free research Free research Free assay review with research home and workspace preview
Quick search ChEMBL 36
Assay Detail

CHEMBL2350282

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Antiviral activity against HCV 1b infected in human HuH7 cells by in vitro replicon assay
ChEMBL ↗
49
Total Activities
37
Compounds Tested
2
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Hepacivirus hominis
Cell Type Huh-7
Confidence 1 — Organism
Curated By Autocuration

Target

Hepatitis C virus (CHEMBL379) ↗
Type ORGANISM
Organism Hepacivirus hominis

Publication

Synthesis and evaluation of non-dimeric HCV NS5A inhibitors.
Amblard F, Zhang H, Zhou L, Shi J, Bobeck DR, Nettles JH, Chavre S, McBrayer TR, Tharnish P, Whitaker T, Coats SJ, Schinazi RF.
Bioorg Med Chem Lett (2013) 23 : 2031 -2034
PubMed 23466233 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
EC50 37 8.13 11.00
EC90 12 - -

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL2023898 DACLATASVIR 4.0 2 11.00
CHEMBL2347323 — — 2 9.15
CHEMBL2347337 — — 2 8.70
CHEMBL2347325 — — 2 8.70
CHEMBL2347324 — — 2 8.40
CHEMBL2347328 — — 2 8.34
CHEMBL2347332 — — 2 8.30
CHEMBL2347159 — — 2 8.10
CHEMBL2347335 — — 2 7.68
CHEMBL2347341 — — 2 6.70
CHEMBL2347317 — — 2 6.52
CHEMBL2347321 — — 1 6.00
CHEMBL2347334 — — 1 -
CHEMBL2347333 — — 1 -
CHEMBL2347331 — — 1 -
CHEMBL2347330 — — 1 -
CHEMBL2347329 — — 1 -
CHEMBL2347327 — — 1 -
CHEMBL2347158 — — 1 -
CHEMBL2347160 — — 1 -
CHEMBL2347161 — — 1 -
CHEMBL2347162 — — 1 -
CHEMBL2347163 — — 1 -
CHEMBL2347164 — — 1 -
CHEMBL2347316 — — 1 -
CHEMBL2347319 — — 1 -
CHEMBL2347320 — — 1 -
CHEMBL2347322 — — 1 -
CHEMBL2347157 — — 1 -
CHEMBL2347326 — — 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL2023898 DACLATASVIR EC50 = 0.01 nM 11.00
CHEMBL2347323 — EC50 = 0.7 nM 9.15
CHEMBL2347325 — EC50 = 2.0 nM 8.70
CHEMBL2347337 — EC50 = 2.0 nM 8.70
CHEMBL2347324 — EC50 = 4.0 nM 8.40
CHEMBL2347328 — EC50 = 4.6 nM 8.34
CHEMBL2347332 — EC50 = 5.0 nM 8.30
CHEMBL2347159 — EC50 = 8.0 nM 8.10
CHEMBL2347335 — EC50 = 21.0 nM 7.68
CHEMBL2347341 — EC50 = 200.0 nM 6.70
CHEMBL2347317 — EC50 = 300.0 nM 6.52
CHEMBL2347321 — EC50 = 1000.0 nM 6.00
CHEMBL2347328 — EC90 = 9.6 nM -
CHEMBL2347330 — EC50 > 100.0 nM -
CHEMBL2347325 — EC90 = 3.0 nM -
CHEMBL2347324 — EC90 = 14.0 nM -
CHEMBL2347323 — EC90 = 2.9 nM -
CHEMBL2347318 — EC90 > 1000.0 nM -
CHEMBL2347317 — EC90 = 900.0 nM -
CHEMBL2347159 — EC90 = 52.0 nM -
CHEMBL2347329 — EC50 > 100.0 nM -
CHEMBL2347343 — EC50 > 100.0 nM -
CHEMBL2347342 — EC50 > 100.0 nM -
CHEMBL2347340 — EC50 > 100.0 nM -
CHEMBL2347339 — EC50 > 100.0 nM -
CHEMBL2347338 — EC50 > 100.0 nM -
CHEMBL2347336 — EC50 > 100.0 nM -
CHEMBL2347334 — EC50 > 100.0 nM -
CHEMBL2347333 — EC50 > 1000.0 nM -
CHEMBL2347341 — EC90 = 300.0 nM -
CHEMBL2347319 — EC50 > 1000.0 nM -
CHEMBL2347331 — EC50 > 100.0 nM -
CHEMBL2347161 — EC50 > 100.0 nM -
CHEMBL2347327 — EC50 > 100.0 nM -
CHEMBL2347326 — EC50 > 100.0 nM -
CHEMBL2347157 — EC50 > 1000.0 nM -
CHEMBL2347158 — EC50 > 100.0 nM -
CHEMBL2347160 — EC50 > 100.0 nM -
CHEMBL2347322 — EC50 > 100.0 nM -
CHEMBL2347320 — EC50 > 1000.0 nM -
CHEMBL2347332 — EC90 = 17.0 nM -
CHEMBL2347318 — EC50 > 100.0 nM -
CHEMBL2347316 — EC50 > 1000.0 nM -
CHEMBL2347164 — EC50 > 1000.0 nM -
CHEMBL2347163 — EC50 > 100.0 nM -
CHEMBL2347162 — EC50 > 100.0 nM -
CHEMBL2023898 DACLATASVIR EC90 = 0.03 nM -
CHEMBL2347337 — EC90 = 9.0 nM -
CHEMBL2347335 — EC90 = 76.0 nM -