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Compound Detail

CHEMBL2347325

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COC(=O)N[C@H](C(=O)N1CCC[C@H]1c1nc(I)c(-c2ccc(N=[N+]=[N-])cc2)[nH]1)C(C)C

Basic Information

ChEMBL ID CHEMBL2347325
Phase Preclinical
Structure Type MOL
InChI Key GRZXTBLXZPXFKC-GJZGRUSLSA-N
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
5
Publications
0
Known Names

Molecular Properties

537.4
MW (Da)
4.67
ALogP
5
HBA
2
HBD
136.1
PSA (Ų)
0.24
QED
1
Ro5 Violations
6
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C20H24IN7O3
MW 537.36
Aromatic Rings 2
Heavy Atoms 31
NP-Likeness -0.74

Activity Summary

EC50 1 meas. best 8.7

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Hepatitis C virus
CHEMBL379
EC50 8.7 8.7 2.0 1

Activity Data Samples

Top measurements by pChEMBL value

Target Type Rel. Value Units pChEMBL Assay PubMed
Hepatitis C virus EC50 = 2.0 nM 8.7 Antiviral activity against HCV 1b infected in human HuH7 cells by in vitro repli... 23466233

Literature References

Data from ChEMBL 36 via Core Engine