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Assay Detail

CHEMBL2350427

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of c-MET phosphorylation (unknown origin) after 1 hr by Z'-LYTE kinase assay
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

Hepatocyte growth factor receptor (CHEMBL3717)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Olive secoiridoids and semisynthetic bioisostere analogues for the control of metastatic breast cancer.
Busnena BA, Foudah AI, Melancon T, El Sayed KA.
Bioorg Med Chem (2013) 21 : 2117 -2127
PubMed 23403296 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 2 5.06 5.26

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL2172394 (-)-OLEOCANTHAL 1 5.26
CHEMBL2348314 TYROSOL SINAPATE 1 4.86

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL2172394 (-)-OLEOCANTHAL IC50 = 5500.0 nM 5.26
CHEMBL2348314 TYROSOL SINAPATE IC50 = 13700.0 nM 4.86