Assay Detail
Functional
CHEMBL2350796
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Reduction in spinal cord neuroinflammation in sc dosed experimental autoimmune encephalomyelitis rat model
2
Total Activities
1
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Rattus norvegicus |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Substituted 7-amino-5-thio-thiazolo[4,5-d]pyrimidines as potent and selective antagonists of the fractalkine receptor (CX3CR1).
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 1 | 5.82 | 5.82 |
| Activity | 1 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2349310 | AZD-8797 | 2.0 | 2 | 5.82 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2349310 | AZD-8797 | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL2349310 | AZD-8797 | Activity | - | — | - |