Assay Detail
Functional
CHEMBL2350895
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Anti-neuroinflammatory activity in mouse BV2 cells assessed as inhibition of LPS-induced nitric oxide production after 10 mins by Griess assay relative to control
16
Total Activities
16
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Cell Type | BV-2 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Quinic acid derivatives from Pimpinella brachycarpa exert anti-neuroinflammatory activity in lipopolysaccharide-induced microglia.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 16 | 4.63 | 5.33 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2349422 | — | — | 1 | 5.33 |
| CHEMBL463337 | — | — | 1 | 5.04 |
| CHEMBL416955 | CHLOROGENIC ACID METHYL ESTER | — | 1 | 4.92 |
| CHEMBL2349423 | — | — | 1 | 4.90 |
| CHEMBL256147 | TILARGININE | 3.0 | 1 | 4.79 |
| CHEMBL2349426 | — | — | 1 | 4.78 |
| CHEMBL2349427 | — | — | 1 | 4.77 |
| CHEMBL516541 | 3,4-O-TRANS-CAFFEOYLQUINIC ACID METHYL ESTER | — | 1 | 4.70 |
| CHEMBL478574 | 1,5-O-TRANS-DICAFFEOYLQUINIC ACID | — | 1 | 4.64 |
| CHEMBL2349421 | — | — | 1 | 4.63 |
| CHEMBL464371 | — | — | 1 | 4.61 |
| CHEMBL2349428 | — | — | 1 | 4.35 |
| CHEMBL2349425 | — | — | 1 | 4.28 |
| CHEMBL2349424 | — | — | 1 | 4.22 |
| CHEMBL2349429 | — | — | 1 | 4.09 |
| CHEMBL2349430 | — | — | 1 | 4.06 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2349422 | — | IC50 | = | 4660.0 | nM | 5.33 |
| CHEMBL463337 | — | IC50 | = | 9040.0 | nM | 5.04 |
| CHEMBL416955 | CHLOROGENIC ACID METHYL ESTER | IC50 | = | 12110.0 | nM | 4.92 |
| CHEMBL2349423 | — | IC50 | = | 12520.0 | nM | 4.90 |
| CHEMBL256147 | TILARGININE | IC50 | = | 16320.0 | nM | 4.79 |
| CHEMBL2349426 | — | IC50 | = | 16570.0 | nM | 4.78 |
| CHEMBL2349427 | — | IC50 | = | 17040.0 | nM | 4.77 |
| CHEMBL516541 | 3,4-O-TRANS-CAFFEOYLQUINIC ACID METHYL ESTER | IC50 | = | 20150.0 | nM | 4.70 |
| CHEMBL478574 | 1,5-O-TRANS-DICAFFEOYLQUINIC ACID | IC50 | = | 22630.0 | nM | 4.64 |
| CHEMBL2349421 | — | IC50 | = | 23530.0 | nM | 4.63 |
| CHEMBL464371 | — | IC50 | = | 24580.0 | nM | 4.61 |
| CHEMBL2349428 | — | IC50 | = | 44990.0 | nM | 4.35 |
| CHEMBL2349425 | — | IC50 | = | 52790.0 | nM | 4.28 |
| CHEMBL2349424 | — | IC50 | = | 59820.0 | nM | 4.22 |
| CHEMBL2349429 | — | IC50 | = | 81970.0 | nM | 4.09 |
| CHEMBL2349430 | — | IC50 | = | 86410.0 | nM | 4.06 |