Assay Detail
Functional
CHEMBL2351847
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Cytotoxicity against mouse BA/F3 cells transfected with wild type Bcr-Abl after 48 hrs by XTT assay
14
Total Activities
13
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Cell Type | BaF3 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Discovery of new benzothiazole-based inhibitors of breakpoint cluster region-Abelson kinase including the T315I mutant.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 13 | 6.92 | 8.64 |
| Inhibition | 1 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1171837 | PONATINIB | 4.0 | 1 | 8.64 |
| CHEMBL2347725 | — | — | 1 | 7.34 |
| CHEMBL2347724 | — | — | 1 | 7.09 |
| CHEMBL2347723 | — | — | 1 | 7.05 |
| CHEMBL941 | IMATINIB | 4.0 | 1 | 7.04 |
| CHEMBL2347722 | — | — | 2 | 7.00 |
| CHEMBL2347729 | — | — | 1 | 6.96 |
| CHEMBL2347728 | — | — | 1 | 6.92 |
| CHEMBL2347727 | — | — | 1 | 6.75 |
| CHEMBL2347726 | — | — | 1 | 6.68 |
| CHEMBL2347730 | — | — | 1 | 6.55 |
| CHEMBL2347731 | — | — | 1 | 6.51 |
| CHEMBL2347710 | — | — | 1 | 5.45 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1171837 | PONATINIB | IC50 | = | 2.3 | nM | 8.64 |
| CHEMBL2347725 | — | IC50 | = | 46.0 | nM | 7.34 |
| CHEMBL2347724 | — | IC50 | = | 82.0 | nM | 7.09 |
| CHEMBL2347723 | — | IC50 | = | 89.0 | nM | 7.05 |
| CHEMBL941 | IMATINIB | IC50 | = | 92.0 | nM | 7.04 |
| CHEMBL2347722 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL2347729 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL2347728 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL2347727 | — | IC50 | = | 180.0 | nM | 6.75 |
| CHEMBL2347726 | — | IC50 | = | 210.0 | nM | 6.68 |
| CHEMBL2347730 | — | IC50 | = | 280.0 | nM | 6.55 |
| CHEMBL2347731 | — | IC50 | = | 310.0 | nM | 6.51 |
| CHEMBL2347710 | — | IC50 | = | 3570.0 | nM | 5.45 |
| CHEMBL2347722 | — | Inhibition | - | % | - |