Assay Detail
Functional
CHEMBL2351848
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Cytotoxicity against mouse BA/F3 cells transfected with Bcr-Abl T315I mutant after 48 hrs by XTT assay
13
Total Activities
12
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Cell Type | BaF3 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Discovery of new benzothiazole-based inhibitors of breakpoint cluster region-Abelson kinase including the T315I mutant.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 12 | 6.20 | 7.11 |
| Inhibition | 1 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2347725 | — | — | 1 | 7.11 |
| CHEMBL2347723 | — | — | 1 | 6.85 |
| CHEMBL2347722 | — | — | 2 | 6.54 |
| CHEMBL2347724 | — | — | 1 | 6.54 |
| CHEMBL2347731 | — | — | 1 | 6.39 |
| CHEMBL2347728 | — | — | 1 | 6.25 |
| CHEMBL2347729 | — | — | 1 | 6.06 |
| CHEMBL2347726 | — | — | 1 | 5.96 |
| CHEMBL2347727 | — | — | 1 | 5.87 |
| CHEMBL2347730 | — | — | 1 | 5.84 |
| CHEMBL2347710 | — | — | 1 | 5.67 |
| CHEMBL941 | IMATINIB | 4.0 | 1 | 5.32 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2347725 | — | IC50 | = | 78.0 | nM | 7.11 |
| CHEMBL2347723 | — | IC50 | = | 140.0 | nM | 6.85 |
| CHEMBL2347724 | — | IC50 | = | 290.0 | nM | 6.54 |
| CHEMBL2347722 | — | IC50 | = | 290.0 | nM | 6.54 |
| CHEMBL2347731 | — | IC50 | = | 410.0 | nM | 6.39 |
| CHEMBL2347728 | — | IC50 | = | 560.0 | nM | 6.25 |
| CHEMBL2347729 | — | IC50 | = | 870.0 | nM | 6.06 |
| CHEMBL2347726 | — | IC50 | = | 1090.0 | nM | 5.96 |
| CHEMBL2347727 | — | IC50 | = | 1350.0 | nM | 5.87 |
| CHEMBL2347730 | — | IC50 | = | 1440.0 | nM | 5.84 |
| CHEMBL2347710 | — | IC50 | = | 2140.0 | nM | 5.67 |
| CHEMBL941 | IMATINIB | IC50 | = | 4790.0 | nM | 5.32 |
| CHEMBL2347722 | — | Inhibition | - | % | - |