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Assay Detail

CHEMBL2351860

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Displacement of [3H]-CGP12177 from human beta2 adrenoceptor expressed in CHOK1 cells after 2 hrs by scintillation counting analysis
30
Total Activities
30
Compounds Tested
2
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Cell Type CHO-K1
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

Beta-2 adrenergic receptor (CHEMBL210)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Synthesis and in vitro and in vivo characterization of highly β1-selective β-adrenoceptor partial agonists.
Mistry SN, Baker JG, Fischer PM, Hill SJ, Gardiner SM, Kellam B.
J Med Chem (2013) 56 : 3852 -3865
PubMed 23614528 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Kd 28 6.02 9.17
Inhibition 2 - -

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL513389 ZENIDOLOL 2.0 1 9.17
CHEMBL3392321 1 6.84
CHEMBL2348198 1 6.54
CHEMBL2348212 1 6.27
CHEMBL2348203 1 6.10
CHEMBL2348213 1 6.06
CHEMBL2348216 1 6.05
CHEMBL2348204 1 5.99
CHEMBL2348209 1 5.96
CHEMBL2348197 1 5.94
CHEMBL2348215 1 5.93
CHEMBL2348199 1 5.92
CHEMBL2348202 1 5.91
CHEMBL2348218 1 5.91
CHEMBL2348205 1 5.86
CHEMBL2348207 1 5.86
CHEMBL2348196 1 5.86
CHEMBL2348210 1 5.85
CHEMBL2348206 1 5.84
CHEMBL280822 CGP-20712A 1 5.82
CHEMBL2348214 1 5.80
CHEMBL2348208 1 5.76
CHEMBL75753 XAMOTEROL 2.0 1 5.76
CHEMBL2348201 1 5.69
CHEMBL2348211 1 5.58
CHEMBL2348200 1 5.54
CHEMBL2348219 1 5.45
CHEMBL207802 LK-204545 1 5.29
CHEMBL2348217 1 -
CHEMBL2348220 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL513389 ZENIDOLOL Kd = 0.6761 nM 9.17
CHEMBL3392321 Kd = 144.54 nM 6.84
CHEMBL2348198 Kd = 288.4 nM 6.54
CHEMBL2348212 Kd = 537.03 nM 6.27
CHEMBL2348203 Kd = 794.33 nM 6.10
CHEMBL2348213 Kd = 870.96 nM 6.06
CHEMBL2348216 Kd = 891.25 nM 6.05
CHEMBL2348204 Kd = 1023.29 nM 5.99
CHEMBL2348209 Kd = 1096.48 nM 5.96
CHEMBL2348197 Kd = 1148.15 nM 5.94
CHEMBL2348215 Kd = 1174.9 nM 5.93
CHEMBL2348199 Kd = 1202.26 nM 5.92
CHEMBL2348202 Kd = 1230.27 nM 5.91
CHEMBL2348218 Kd = 1230.27 nM 5.91
CHEMBL2348205 Kd = 1380.38 nM 5.86
CHEMBL2348207 Kd = 1380.38 nM 5.86
CHEMBL2348196 Kd = 1380.38 nM 5.86
CHEMBL2348210 Kd = 1412.54 nM 5.85
CHEMBL2348206 Kd = 1445.44 nM 5.84
CHEMBL280822 CGP-20712A Kd = 1513.56 nM 5.82
CHEMBL2348214 Kd = 1584.89 nM 5.80
CHEMBL2348208 Kd = 1737.8 nM 5.76
CHEMBL75753 XAMOTEROL Kd = 1737.8 nM 5.76
CHEMBL2348201 Kd = 2041.74 nM 5.69
CHEMBL2348211 Kd = 2630.27 nM 5.58
CHEMBL2348200 Kd = 2884.03 nM 5.54
CHEMBL2348219 Kd = 3548.13 nM 5.45
CHEMBL207802 LK-204545 Kd = 5128.61 nM 5.29
CHEMBL2348217 Inhibition - % -
CHEMBL2348220 Inhibition - % -