Assay Detail
Binding
CHEMBL2352544
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of diphenolase activity of mushroom tyrosinase assessed as decrease in L-DOPA chrome formation using L-DOPA as substrate preincubated with enzyme for 10 mins prior to substrate addition measured for 10 mins by spectrophotometric assay
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Agaricus bisporus |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Synthesis of novel azo compounds containing 5(4H)-oxazolone ring as potent tyrosinase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 5.43 | 5.84 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2348690 | — | — | 1 | 5.84 |
| CHEMBL2348689 | — | — | 1 | 5.70 |
| CHEMBL2348688 | — | — | 1 | 5.52 |
| CHEMBL245416 | L-MIMOSINE | — | 1 | 5.43 |
| CHEMBL2348687 | — | — | 1 | 5.41 |
| CHEMBL2348686 | — | — | 1 | 5.40 |
| CHEMBL2348685 | — | — | 1 | 5.36 |
| CHEMBL287556 | KOJIC ACID | — | 1 | 4.78 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2348690 | — | IC50 | = | 1440.0 | nM | 5.84 |
| CHEMBL2348689 | — | IC50 | = | 2010.0 | nM | 5.70 |
| CHEMBL2348688 | — | IC50 | = | 3040.0 | nM | 5.52 |
| CHEMBL245416 | L-MIMOSINE | IC50 | = | 3680.0 | nM | 5.43 |
| CHEMBL2348687 | — | IC50 | = | 3910.0 | nM | 5.41 |
| CHEMBL2348686 | — | IC50 | = | 3980.0 | nM | 5.40 |
| CHEMBL2348685 | — | IC50 | = | 4330.0 | nM | 5.36 |
| CHEMBL287556 | KOJIC ACID | IC50 | = | 16670.0 | nM | 4.78 |