Skip to main content
Free research Free research Free compound review with research home and workspace preview
Quick search ChEMBL 36
Compound Detail

CHEMBL245416

L-MIMOSINE
Enter ChEMBL ID:
Free Research Context This compound will appear in recent viewed items on the research home for this browser.
Research home View demo workspace
N[C@@H](Cn1ccc(=O)c(O)c1)C(=O)O
ChEMBL ↗ Properties Compare Identifier

Basic Information

ChEMBL ID CHEMBL245416
Name L-MIMOSINE
Phase Preclinical
Structure Type MOL
InChI Key WZNJWVWKTVETCG-YFKPBYRVSA-N
5
Targets
10
Activities
2
Assay Types
0
PK Parameters
20
Publications
0
Known Names

Molecular Properties

198.2
MW (Da)
-1.03
ALogP
5
HBA
3
HBD
105.5
PSA (Ų)
0.58
QED
0
Ro5 Violations
3
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

Natural Product First in Class Prodrug

Extended Properties

Molecular Formula C8H10N2O4
MW 198.18
Aromatic Rings 1
Heavy Atoms 14
NP-Likeness 0.73

Activity Summary

IC50 6 meas. best 5.43
Ki 4 meas. best 5.1

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Tyrosinase
CHEMBL3318
 IC50 5.43 5.43 3680.0 3
Deoxyhypusine hydroxylase
CHEMBL4523441
 IC50 5.3 5.3 5000.0 1
Unchecked
CHEMBL612545
 Ki 5.1 4.685 8000.0 2
Tyrosinase
CHEMBL1973
 Ki 5.0 4.995 10000.0 2
Plasmodium falciparum
CHEMBL364
 IC50 4.5 4.455 32000.0 2

Activity Data Samples

Top measurements by pChEMBL value

Target Type Rel. Value Units pChEMBL Assay PubMed
Tyrosinase IC50 = 3680.0 nM 5.43 Inhibition of mushroom tyrosinase after 10 mins 17110117
Tyrosinase IC50 = 3680.0 nM 5.43 Inhibition of mashroom tyrosinase 17637486
Tyrosinase IC50 = 3680.0 nM 5.43 Inhibition of diphenolase activity of mushroom tyrosinase assessed as decrease i... 23411395
Deoxyhypusine hydroxylase IC50 = 5000.0 nM 5.3 Inhibition of DOHH (unknown origin) 30684796
Unchecked Ki = 8000.0 nM 5.1 Binding affinity to Mushroom Tyrosinase assessed as inhibition constant 37487307
Tyrosinase Ki = 10000.0 nM 5.0 Binding affinity to human recombinant Tyrosinase expressed in Sf9 assessed as in... 37487307
Tyrosinase Ki = 10300.0 nM 4.99 Competitive inhibition of recombinant human tyrosinase expressed in baculovirus ... 32787103
Plasmodium falciparum IC50 = 32000.0 nM 4.5 Antiplasmodial activity against chloroquine-sensitive Plasmodium falciparum 18159921
Plasmodium falciparum IC50 = 39000.0 nM 4.41 Antiplasmodial activity against chloroquine-resistant Plasmodium falciparum 18159921
Unchecked Ki = 54000.0 nM 4.27 Binding affinity to bacterial Tyrosinase assessed as inhibition constant 37487307

Literature References

PubMed DOI Target Context # Activities
37468498 10.1038/s41467-023-40064-9 Mu-type opioid receptor 2
18159921 10.1021/jm070763y Plasmodium falciparum 2
37468498 10.1038/s41467-023-40064-9 5-hydroxytryptamine receptor 2A 2
37468498 10.1038/s41467-023-40064-9 Type-1 angiotensin II receptor 2
37487307 10.1016/j.ejmech.2023.115672 Unchecked 2
37468498 10.1038/s41467-023-40064-9 5-hydroxytryptamine receptor 1A 2
37468498 10.1038/s41467-023-40064-9 Gamma-aminobutyric acid receptor subunit alpha-1 2
37468498 10.1038/s41467-023-40064-9 5-hydroxytryptamine receptor 2B 2
37468498 10.1038/s41467-023-40064-9 Alpha-2A adrenergic receptor 2
37468498 10.1038/s41467-023-40064-9 Muscarinic acetylcholine receptor M2 2
37468498 10.1038/s41467-023-40064-9 Progesterone receptor 2
37468498 10.1038/s41467-023-40064-9 Voltage-dependent L-type calcium channel subunit alpha-1C 1
37468498 10.1038/s41467-023-40064-9 Kappa-type opioid receptor 1
37468498 10.1038/s41467-023-40064-9 Beta-2 adrenergic receptor 1
37468498 10.1038/s41467-023-40064-9 Beta-1 adrenergic receptor 1
37468498 10.1038/s41467-023-40064-9 Glutamate receptor ionotropic, NMDA 1 1
37468498 10.1038/s41467-023-40064-9 Type-2 angiotensin II receptor 1
32787103 10.1021/acs.jmedchem.0c00994 Tyrosinase 1
23411395 10.1016/j.bmc.2013.01.014 Tyrosinase 1
23062825 10.1016/j.bmc.2012.09.040 Cholinesterase 1

Data from ChEMBL 36 via Core Engine