Assay Detail
Binding
CHEMBL2352940
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Inhibition of human recombinant MPO-mediated taurine chlorination after 5 mins by microplate assay
34
Total Activities
34
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Tissue | Urine |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Design, synthesis, and structure-activity relationship studies of novel 3-alkylindole derivatives as selective and highly potent myeloperoxidase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 34 | 7.57 | 8.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2347170 | — | — | 1 | 8.52 |
| CHEMBL2347168 | — | — | 1 | 8.40 |
| CHEMBL2347177 | — | — | 1 | 8.30 |
| CHEMBL2347032 | — | — | 1 | 8.22 |
| CHEMBL2347166 | — | — | 1 | 8.00 |
| CHEMBL2347167 | — | — | 1 | 8.00 |
| CHEMBL2347176 | — | — | 1 | 7.96 |
| CHEMBL2347165 | — | — | 1 | 7.89 |
| CHEMBL2346670 | — | — | 1 | 7.85 |
| CHEMBL2347181 | — | — | 1 | 7.75 |
| CHEMBL2347034 | — | — | 1 | 7.66 |
| CHEMBL2347030 | — | — | 1 | 7.62 |
| CHEMBL2347024 | — | — | 1 | 7.58 |
| CHEMBL205229 | — | — | 1 | 7.54 |
| CHEMBL2347027 | — | — | 1 | 7.47 |
| CHEMBL2347169 | — | — | 1 | 7.46 |
| CHEMBL2347175 | — | — | 1 | 7.43 |
| CHEMBL2347026 | — | — | 1 | 7.41 |
| CHEMBL2347028 | — | — | 1 | 7.40 |
| CHEMBL2347178 | — | — | 1 | 7.22 |
| CHEMBL2347179 | — | — | 1 | 7.20 |
| CHEMBL2347025 | — | — | 1 | 6.88 |
| CHEMBL2347029 | — | — | 1 | 6.74 |
| CHEMBL2347182 | — | — | 1 | 6.57 |
| CHEMBL6640 | TRYPTAMINE | — | 1 | 6.11 |
| CHEMBL39 | SEROTONIN | 3.0 | 1 | - |
| CHEMBL925 | TYROSINE | 4.0 | 1 | - |
| CHEMBL2347171 | — | — | 1 | - |
| CHEMBL2347172 | — | — | 1 | - |
| CHEMBL2347033 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2347170 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL2347168 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL2347177 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL2347032 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL2347166 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL2347167 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL2347176 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL2347165 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL2346670 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL2347181 | — | IC50 | = | 18.0 | nM | 7.75 |
| CHEMBL2347034 | — | IC50 | = | 22.0 | nM | 7.66 |
| CHEMBL2347030 | — | IC50 | = | 24.0 | nM | 7.62 |
| CHEMBL2347024 | — | IC50 | = | 26.0 | nM | 7.58 |
| CHEMBL205229 | — | IC50 | = | 29.0 | nM | 7.54 |
| CHEMBL2347027 | — | IC50 | = | 34.0 | nM | 7.47 |
| CHEMBL2347169 | — | IC50 | = | 35.0 | nM | 7.46 |
| CHEMBL2347175 | — | IC50 | = | 37.0 | nM | 7.43 |
| CHEMBL2347026 | — | IC50 | = | 39.0 | nM | 7.41 |
| CHEMBL2347028 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL2347178 | — | IC50 | = | 60.0 | nM | 7.22 |
| CHEMBL2347179 | — | IC50 | = | 63.0 | nM | 7.20 |
| CHEMBL2347025 | — | IC50 | = | 132.0 | nM | 6.88 |
| CHEMBL2347029 | — | IC50 | = | 182.0 | nM | 6.74 |
| CHEMBL2347182 | — | IC50 | = | 271.0 | nM | 6.57 |
| CHEMBL6640 | TRYPTAMINE | IC50 | = | 770.0 | nM | 6.11 |
| CHEMBL39 | SEROTONIN | IC50 | - | — | - | |
| CHEMBL925 | TYROSINE | IC50 | - | — | - | |
| CHEMBL2347171 | — | IC50 | > | 100.0 | nM | - |
| CHEMBL2347172 | — | IC50 | > | 100.0 | nM | - |
| CHEMBL2347033 | — | IC50 | - | — | - | |
| CHEMBL2347173 | — | IC50 | > | 100.0 | nM | - |
| CHEMBL2347031 | — | IC50 | - | — | - | |
| CHEMBL2347174 | — | IC50 | > | 100.0 | nM | - |
| CHEMBL2347180 | — | IC50 | - | — | - |